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AG 337

Known as: AG-337, AG337 
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
BACKGROUND Some anticancer drugs inhibit thymidylate synthase (TS), a key enzyme for thymidine nucleotide biosynthesis. Cells can… 
Review
2000
Review
2000
Thymidylate synthase (TS) is an essential enzyme for the de novo synthesis of thymidylate and subsequently DNA synthesis. TS has… 
Highly Cited
2000
Highly Cited
2000
Thymidylate synthase (TS) is an important target for cancer chemotherapy. However, several mechanisms of resistance to TS… 
Highly Cited
2000
Highly Cited
2000
We have studied the molecular basis for the resistance of human CEM leukemia cells to GW1843, a thymidylate synthase inhibitor… 
Highly Cited
1999
Highly Cited
1999
Thymidylate synthase (TS), a critical enzyme in the de novo synthesis of thymidylate, is an important target for… 
Review
1999
Review
1999
In this review, we describe the role of thymidylate synthase (TS) as a determinant of chemotherapeutic response. TS is an… 
Highly Cited
1997
Highly Cited
1997
Oxaliplatin, classical [5-fluorouracil (5-FU)] and non-classical (AG337) thymidylate synthase inhibitors have shown promising… 
Review
1997
Review
1997
PURPOSE AND METHODS Although fluoropyrimidines, in particular, fluorouracil (5-FU) and fluorodeoxyuridine (FdUrd), are active… 
Review
1995
Review
1995
The enzyme, thymidylate synthase (TS) is considered an important target for the development of new anticancer agents. Moreover…