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AG 337

Known as: AG-337, AG337 
National Institutes of Health

Papers overview

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2006
2006
PurposeWe recently showed an increase in tumour uptake of 2-[11C]thymidine in patients with gastrointestinal malignancies after… 
Highly Cited
2003
Highly Cited
2003
BACKGROUND Some anticancer drugs inhibit thymidylate synthase (TS), a key enzyme for thymidine nucleotide biosynthesis. Cells can… 
1998
1998
Leukemic cells of 27 children [14 patients with initial acute lymphoblastic leukemia (iALL), 8 patients with relapsed ALL (rALL… 
1998
1998
The purpose of this study was to determine the intestinal absorption characteristics of AG337, a mechanism-based inhibitor of… 
1997
1997
Purpose: To establish the maximum tolerated dose (MTD), dose-limiting and other major toxicities and the major pharmacokinetic… 
Review
1997
Review
1997
Many novel antifolate compounds with unique pharmacologic properties are currently in clinical development. These newer… 
1995
1995
3,4-Dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)quinazobone dihydrochboride (AG337) is a nonclassical inhibitor of… 
Review
1994
Review
1994
Thymidylate synthase (TS) is regarded as a good target for the development of quinazoline (folate-based) anticancer agents. The…