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AG 337
Known as:
AG-337
, AG337
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (3)
Quinazolines
nolatrexed
nolatrexed dihydrochloride
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
2-[11C]thymidine positron emission tomography as an indicator of thymidylate synthase inhibition in patients treated with AG337.
P. Wells
,
E. Aboagye
,
+8 authors
D. Newell
Journal of the National Cancer Institute
2003
Corpus ID: 19755363
BACKGROUND Some anticancer drugs inhibit thymidylate synthase (TS), a key enzyme for thymidine nucleotide biosynthesis. Cells can…
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Review
2000
Review
2000
Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors.
B. van Triest
,
H. Pinedo
,
G. Giaccone
,
G. Peters
Annals of oncology : official journal of the…
2000
Corpus ID: 5022758
Thymidylate synthase (TS) is an essential enzyme for the de novo synthesis of thymidylate and subsequently DNA synthesis. TS has…
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Highly Cited
2000
Highly Cited
2000
Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues.
S. Welsh
,
J. Titley
,
+4 authors
G. Aherne
Clinical cancer research : an official journal of…
2000
Corpus ID: 28898264
Thymidylate synthase (TS) is an important target for cancer chemotherapy. However, several mechanisms of resistance to TS…
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Highly Cited
2000
Highly Cited
2000
Clustering of Mutations in the First Transmembrane Domain of the Human Reduced Folate Carrier in GW1843U89-resistant Leukemia Cells with Impaired Antifolate Transport and Augmented Folate Uptake*
S. Drori
,
G. Jansen
,
R. Mauritz
,
G. Peters
,
Y. Assaraf
The Journal of Biological Chemistry
2000
Corpus ID: 10282439
We have studied the molecular basis for the resistance of human CEM leukemia cells to GW1843, a thymidylate synthase inhibitor…
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Highly Cited
2000
Highly Cited
2000
Cross-resistance in the 2',2'-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 to standard and investigational drugs.
A. Bergman
,
G. Giaccone
,
+4 authors
G. Peters
European journal of cancer
2000
Corpus ID: 37259381
Highly Cited
1999
Highly Cited
1999
Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.
B. van Triest
,
H. Pinedo
,
+8 authors
G. Peters
Clinical cancer research : an official journal of…
1999
Corpus ID: 5985076
Thymidylate synthase (TS), a critical enzyme in the de novo synthesis of thymidylate, is an important target for…
Expand
Review
1999
Review
1999
Thymidylate Synthase: A Target for Combination Therapy and Determinant of Chemotherapeutic Response in Colorectal Cancer
B. van Triest
,
G. J. Peters
Oncology
1999
Corpus ID: 40802412
In this review, we describe the role of thymidylate synthase (TS) as a determinant of chemotherapeutic response. TS is an…
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Highly Cited
1997
Highly Cited
1997
Antitumor activity of oxaliplatin in combination with 5-fluorouracil and the thymidylate synthase inhibitor AG337 in human colon, breast and ovarian cancers
E. Raymond
,
C. Buquet-Fagot
,
+5 authors
C. Gespach
Anti-cancer drugs
1997
Corpus ID: 12705711
Oxaliplatin, classical [5-fluorouracil (5-FU)] and non-classical (AG337) thymidylate synthase inhibitors have shown promising…
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Review
1997
Review
1997
Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors.
Y. Rustum
,
A. Harstrick
,
+4 authors
S. Seeber
Journal of clinical oncology : official journal…
1997
Corpus ID: 20596123
PURPOSE AND METHODS Although fluoropyrimidines, in particular, fluorouracil (5-FU) and fluorodeoxyuridine (FdUrd), are active…
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Review
1995
Review
1995
Folate-based thymidylate synthase inhibitors as anticancer drugs.
A. Jackman
,
A. Calvert
Annals of oncology : official journal of the…
1995
Corpus ID: 12120160
The enzyme, thymidylate synthase (TS) is considered an important target for the development of new anticancer agents. Moreover…
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