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AG 337

Known as: AG-337, AG337 
 
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
BACKGROUND Some anticancer drugs inhibit thymidylate synthase (TS), a key enzyme for thymidine nucleotide biosynthesis. Cells can… Expand
Review
2000
Review
2000
Thymidylate synthase (TS) is an essential enzyme for the de novo synthesis of thymidylate and subsequently DNA synthesis. TS has… Expand
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Highly Cited
2000
Highly Cited
2000
Thymidylate synthase (TS) is an important target for cancer chemotherapy. However, several mechanisms of resistance to TS… Expand
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Highly Cited
2000
Highly Cited
2000
Gemcitabine (2'-2'-difluorodeoxycytidine; dFdC) is a deoxycytidine analogue which is effective against solid tumours, including… Expand
Highly Cited
2000
Highly Cited
2000
We have studied the molecular basis for the resistance of human CEM leukemia cells to GW1843, a thymidylate synthase inhibitor… Expand
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Highly Cited
1999
Highly Cited
1999
Thymidylate synthase (TS), a critical enzyme in the de novo synthesis of thymidylate, is an important target for… Expand
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Highly Cited
1997
Highly Cited
1997
Oxaliplatin, classical [5-fluorouracil (5-FU)] and non-classical (AG337) thymidylate synthase inhibitors have shown promising… Expand
Highly Cited
1996
Highly Cited
1996
Abstract 3,4-Dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)-quinazoline dihydrochloride (AG337) is a water-soluble, lipophilic… Expand
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1996
1996
  • Takimoto
  • The oncologist
  • 1996
  • Corpus ID: 11406217
Many new antifolate compounds with unique clinical properties are currently in clinical development. Some of these agents have… Expand
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Review
1995
Review
1995
The enzyme, thymidylate synthase (TS) is considered an important target for the development of new anticancer agents. Moreover… Expand
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