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Charcot-Marie-Tooth disease (CMT) is the commonest form of inherited neuropathy and has an incidence of 1/2500. CMT1A is the… Expand Charcot‑Marie‑Tooth type 1A (CMT1A) is a dysmyelinating disease of the peripheral nervous system that results in a slow… Expand GABAergic signaling is involved in modulating the reinforcing properties of alcohol, and GABAB receptors have been proposed as a… Expand ABSTRACT Positive allosteric modulation of the GABAB receptor is a promising alternative to direct activation of the receptor as… Expand ABSTRACT We tested novel positive allosteric modulators (PAMs) of the &ggr;‐aminobutyric acid receptor B (GABAB), ADX71943 and… Expand &NA; Therapeutic use of GABAB receptor agonists for conditions like chronic abdominal pain, overactive bladder (OAB) and… Expand This article is a Commentary on Kalinichev M, Palea S, Haddouk H, Royer‐Urios I, Guilloteau V, Lluel P, Schneider M, Saporito M… Expand The GABAB receptor agonist baclofen reduces urethral resistance and detrusor overactivity in patients with spasticity. However… Expand RationaleA promising pharmacotherapy for alcohol use disorders has been positive allosteric modulators (PAMs) of the… Expand INTRODUCTION AND OBJECTIVES: GABA is important for micturition control. The GABA-BR agonist baclofen reduces urethral resistance… Expand