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ADL5859
Known as:
ADL 5859
, ADL-5859
National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Targeting delta opioid receptors for pain treatment: drugs in phase I and II clinical development
V. Spahn
,
C. Stein
Expert Opinion on Investigational Drugs
2017
Corpus ID: 22258505
ABSTRACT Introduction: Opioids are widely used to treat severe pain. Most clinically used opioids activate µ-opioid receptors…
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2016
2016
Synergistic antidepressant-like effects between a kappa opioid antagonist (LY2444296) and a delta opioid agonist (ADL5859) in the mouse forced swim test.
Peng Huang
,
J. Tunis
,
Christopher Parry
,
R. Tallarida
,
L. Liu-Chen
European Journal of Pharmacology
2016
Corpus ID: 19824887
2015
2015
Delta opioid receptors expressed in forebrain GABAergic neurons are responsible for SNC80-induced seizures
P. C. S. Chung
,
Annie Boehrer
,
+5 authors
B. Kieffer
Behavioural Brain Research
2015
Corpus ID: 205889640
2014
2014
In vivo properties of KNT‐127, a novel δ opioid receptor agonist: receptor internalization, antihyperalgesia and antidepressant effects in mice
C. Nozaki
,
H. Nagase
,
T. Nemoto
,
A. Matifas
,
B. Kieffer
,
C. Gaveriaux-Ruff
British Journal of Pharmacology
2014
Corpus ID: 43085795
Activation of δ opioid (DOP) receptors regulates pain and emotional responses, and also displays ligand‐biased agonism. KNT‐127…
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2013
2013
Novel Screening Assay for the Selective Detection of G-Protein-Coupled Receptor Heteromer Signaling
R. V. van Rijn
,
Jessica H. Harvey
,
D. Brissett
,
Julia N. DeFriel
,
J. Whistler
Journal of Pharmacology and Experimental…
2013
Corpus ID: 33596264
Drugs targeting G-protein-coupled receptors (GPCRs) make up more than 25% of all prescribed medicines. The ability of GPCRs to…
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Highly Cited
2012
Highly Cited
2012
δ-Opioid Mechanisms for ADL5747 and ADL5859 Effects in Mice: Analgesia, Locomotion, and Receptor Internalization
C. Nozaki
,
B. Le Bourdonnec
,
+5 authors
C. Gaveriaux-Ruff
Journal of Pharmacology and Experimental…
2012
Corpus ID: 27327436
N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl) benzamide (ADL5859) and N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4…
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2012
2012
Delta opioid mechanisms for ADL 5747 and ADL 5859 effects in mice : analgesia , locomotion and receptor internalization
C. Nozaki
,
B. L. Bourdonnec
,
+5 authors
C. Gaveriaux-Ruff
2012
Corpus ID: 42875685
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique/Institut National de…
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Highly Cited
2009
Highly Cited
2009
Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747).
B. Le Bourdonnec
,
R. Windh
,
+20 authors
R. Dolle
Journal of Medicinal Chemistry
2009
Corpus ID: 31909211
Selective, nonpeptidic delta opioid receptor agonists have been the subject of great interest as potential novel analgesic agents…
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Highly Cited
2008
Highly Cited
2008
Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).
B. Le Bourdonnec
,
R. Windh
,
+20 authors
R. Dolle
Journal of Medicinal Chemistry
2008
Corpus ID: 36057619
Selective delta opioid receptor agonists are promising potential therapeutic agents for the treatment of various types of pain…
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