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ADL5859

Known as: ADL 5859, ADL-5859 
 
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Targeting delta opioid receptors for pain treatment: drugs in phase I and II clinical development
ABSTRACT Introduction: Opioids are widely used to treat severe pain. Most clinically used opioids activate µ-opioid receptors… Expand
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2016
2016
Synergistic antidepressant-like effects between a kappa opioid antagonist (LY2444296) and a delta opioid agonist (ADL5859) in the mouse forced swim test.
Kappa opioid (KOP) receptor antagonists and delta opioid (DOP) receptor agonists have antidepressant-like effects in animal tests… Expand
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2015
2015
Delta opioid receptors expressed in forebrain GABAergic neurons are responsible for SNC80-induced seizures
The delta opioid receptor (DOR) has raised much interest for the development of new therapeutic drugs, particularly to treat… Expand
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2014
2014
In vivo properties of KNT-127, a novel δ opioid receptor agonist: receptor internalization, antihyperalgesia and antidepressant effects in mice.
BACKGROUND AND PURPOSE Activation of δ opioid (DOP) receptors regulates pain and emotional responses, and also displays ligand… Expand
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2013
2013
Novel Screening Assay for the Selective Detection of G-Protein-Coupled Receptor Heteromer Signaling
Drugs targeting G-protein-coupled receptors (GPCRs) make up more than 25% of all prescribed medicines. The ability of GPCRs to… Expand
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2012
2012
δ-Opioid Mechanisms for ADL5747 and ADL5859 Effects in Mice: Analgesia, Locomotion, and Receptor Internalization
N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl) benzamide (ADL5859) and N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4… Expand
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2012
2012
Delta opioid mechanisms for ADL 5747 and ADL 5859 effects in mice : analgesia , locomotion and receptor internalization
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique/Institut National de… Expand
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2009
2009
Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747).
Selective, nonpeptidic delta opioid receptor agonists have been the subject of great interest as potential novel analgesic agents… Expand
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2008
2008
Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).
Selective delta opioid receptor agonists are promising potential therapeutic agents for the treatment of various types of pain… Expand
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