ADI PEG20

Known as: Pegylated Arginine Deiminase, ADI-PEG20, ADI-PEG 
An agent consisting of the arginine-degrading enzyme arginine deiminase combined with polyethylene glycol (20,000 MW) (ADI-PEG 20) with potential… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2002-2018
0520022018

Papers overview

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2016
2016
The hypoxic tumour microenvironment represents an aggressive, therapy-resistant compartment. As arginine is required for specific… (More)
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2013
2013
BACKGROUND Loss of function of fumarate hydratase (FH), the mitochondrial tumor suppressor and tricarboxylic acid (TCA) cycle… (More)
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2012
2012
Background:Some cancers have been shown to lack expression of argininosuccinate synthetase (ASS), an enzyme required for the… (More)
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2012
2012
Background Arginine deiminase (ADI) is an enzyme that degrades arginine, an amino acid that is important for growth and… (More)
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2010
2010
Current treatment for advanced, metastatic melanoma is not very effective, and new modalities are needed. ADI-PEG20 is a drug… (More)
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2010
2010
Background:Human hepatocellular carcinoma (HCC) cells are largely deficient of argininosuccinate synthetase and thus auxotrophic… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE It is well known that hepatocellular carcinoma (HCC) is an arginine auxotroph due to argininosuccinate synthetase I… (More)
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2007
2007
Recently, pegylated arginine deiminase (ADI; EC 3.5.3.6) has been used to treat the patients with hepatocellular carcinoma or… (More)
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2006
2006
8045 Background: Melanoma cells may be sensitive to arginine (Arg) deprivation due to lack of expression of argininosuccinate… (More)
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2002
2002
Some tumors, such as melanomas and hepatocellular carcinomas, have a unique nutritional requirement for arginine. Thus, enzymatic… (More)
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