ADAMTS5 Protein

Known as: ADAMTS11 Protein, ADAMTS5 Protein [Chemical/Ingredient], ADAMTS 5 Protein 
An ADAMTS protease that contains two C-terminal thrombospondin (TS) motifs. It functions primarily as an aggrecanase, cleaving AGGRECAN in CARTILAGE… (More)
National Institutes of Health

Papers overview

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2007
2007
OBJECTIVE Osteoarthritis (OA) is characterized by damaged articular cartilage and changes in subchondral bone. Previous work… (More)
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2007
2007
OBJECTIVE To determine effects of glucosamine (GLN) and chondroitin sulfate (CS) on expression of genes encoding putative… (More)
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2007
2007
To identify the relationship between T-2 toxin and Kashin-Beck disease (KBD), the effects of T-2 toxin on aggrecan metabolism in… (More)
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Highly Cited
2006
Highly Cited
2006
OBJECTIVE Activated synoviocytes play important roles in the progression of human osteoarthritis (OA). Intra-articular injection… (More)
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2006
2006
Protein kinase Czeta (PKCzeta) is an intracellular serine/threonine protein kinase that has been implicated in the signaling… (More)
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Highly Cited
2005
Highly Cited
2005
Human osteoarthritis is a progressive disease of the joints characterized by degradation of articular cartilage. Although disease… (More)
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2004
2004
OBJECTIVE To determine whether aggrecanase (ADAMTS) activities in articular cartilage can directly lead to the release of… (More)
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Highly Cited
2001
Highly Cited
2001
INTRODUCTION Cleavage of aggrecan between residues Glu(373)-Ala(374), which is believed to be a key event in aggrecan destruction… (More)
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2000
2000
Elevated concentrations of interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) in the synovial fluids and serum of patients… (More)
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Highly Cited
1999
Highly Cited
1999
Aggrecan is responsible for the mechanical properties of cartilage. One of the earliest changes observed in arthritis is the… (More)
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