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ADAMTS5 Protein

Known as: ADAMTS11 Protein, ADAMTS5 Protein [Chemical/Ingredient], ADAMTS 5 Protein 
An ADAMTS protease that contains two C-terminal thrombospondin (TS) motifs. It functions primarily as an aggrecanase, cleaving AGGRECAN in CARTILAGE… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Aggrecan loss from cartilage in arthritis is mediated by aggrecanases. Aggrecanases cleave aggrecan preferentially in the… Expand
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Highly Cited
2006
Highly Cited
2006
OBJECTIVE Activated synoviocytes play important roles in the progression of human osteoarthritis (OA). Intra-articular injection… Expand
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Highly Cited
2006
Highly Cited
2006
OBJECTIVE To investigate the effect of glucosamine (GlcN) in a human osteoarthritic explant model on expression of genes involved… Expand
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Highly Cited
2006
Highly Cited
2006
Aggrecanases are ADAMTS (a disintegrin and metalloproteinase with thrombospondin type I motifs) proteases capable of primary… Expand
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Highly Cited
2005
Highly Cited
2005
Human osteoarthritis is a progressive disease of the joints characterized by degradation of articular cartilage. Although disease… Expand
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Highly Cited
2002
Highly Cited
2002
ADAM-TS5 (aggrecanase 2), one of two cartilage aggrecanases is a member of the ADAM protein family. Like ADAM-TS4 (aggrecanase 1… Expand
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Highly Cited
2002
Highly Cited
2002
Aggrecanases are key matrix-degrading enzymes that act by cleaving aggrecan at the Glu373-Ala374 site. While these fragments have… Expand
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Highly Cited
2001
Highly Cited
2001
INTRODUCTION Cleavage of aggrecan between residues Glu(373)-Ala(374), which is believed to be a key event in aggrecan destruction… Expand
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Highly Cited
2001
Highly Cited
2001
ADAMTS proteinases, belonging to the adamalysin subfamily of metalloproteinases, have been implicated in a variety of cellular… Expand
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Highly Cited
1999
Highly Cited
1999
Aggrecan is responsible for the mechanical properties of cartilage. One of the earliest changes observed in arthritis is the… Expand
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