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Aggrecan loss from cartilage in arthritis is mediated by aggrecanases. Aggrecanases cleave aggrecan preferentially in the… Expand OBJECTIVE
Activated synoviocytes play important roles in the progression of human osteoarthritis (OA). Intra-articular injection… Expand OBJECTIVE
To investigate the effect of glucosamine (GlcN) in a human osteoarthritic explant model on expression of genes involved… Expand Aggrecanases are ADAMTS (a disintegrin and metalloproteinase with thrombospondin type I motifs) proteases capable of primary… Expand Human osteoarthritis is a progressive disease of the joints characterized by degradation of articular cartilage. Although disease… Expand ADAM-TS5 (aggrecanase 2), one of two cartilage aggrecanases is a member of the ADAM protein family. Like ADAM-TS4 (aggrecanase 1… Expand Aggrecanases are key matrix-degrading enzymes that act by cleaving aggrecan at the Glu373-Ala374 site. While these fragments have… Expand INTRODUCTION
Cleavage of aggrecan between residues Glu(373)-Ala(374), which is believed to be a key event in aggrecan destruction… Expand ADAMTS proteinases, belonging to the adamalysin subfamily of metalloproteinases, have been implicated in a variety of cellular… Expand Aggrecan is responsible for the mechanical properties of cartilage. One of the earliest changes observed in arthritis is the… Expand