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ADAMTS5 Protein
Known as:
ADAMTS11 Protein
, ADAMTS5 Protein [Chemical/Ingredient]
, ADAMTS 5 Protein
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An ADAMTS protease that contains two C-terminal thrombospondin (TS) motifs. It functions primarily as an aggrecanase, cleaving AGGRECAN in CARTILAGE…
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National Institutes of Health
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9 relations
ADAMTS5 gene
In Blood
Process of secretion
antagonists & inhibitors
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ADAMTS5 protein, human
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
ADAMTs-5 在颞下颌关节骨关节病大鼠髁突软骨中的表达和意义
李文
,
吕燕
,
丁王辉
,
施洁珺
,
沈晨
,
范媛
2014
Corpus ID: 201990255
2012
2012
Effects of Inhibiting Aggrecanase-2 Gene Expression by RNA Interference on Cultured Chondrocyte Extracellular Matrix in Vitro
Chang Huimin
2012
Corpus ID: 102112649
Objective To evaluate the effect of RNAi mediated aggrecanase-2 on rat costochondral chondrocytes extracelluler matrix.Methods…
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2010
2010
Analysis of Adamts5 (aggrecanase-2) expression in the murine musculoskeletal system and in an ex-vivo model of joint inflammation
J. D. Wiley
,
D. McCulloch
,
S. Apte
2010
Corpus ID: 73751757
INTRODUCTION ADAMTS5 cleaves the extracellular matrix (ECM) proteoglycans aggrecan and versican, which are major components of…
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2010
2010
Pro-inflammatory cytokine expression in synovium , synovial fluid , and articular cartilage of naturally osteoarthritic equine carpi
Kamm
2010
Corpus ID: 40480787
Introduction: Many cytokines including tumor necrosis factor alpha (TNFα) and interleukin one beta (IL-1β) are increased in…
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2009
2009
Aggrecanase Activity and Proteoglycan Release from Human Articular Cartilage as modulated by Tetracyclines
2009
Corpus ID: 27232307
INTRODUCTION: The degradation of aggrecan during osteoarthritis (OA) is catalyzed by increased activities of matrix…
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2009
2009
ADAMTS-5 Inhibition is Required for Potent Inhibition of Aggrecan Degradation in IL-1 ∝ Stimulated Bovine Cartilage Explant Culture
1. Keohan
,
1. Chockalingam
,
1. Eastwood
,
3. Cunningham
,
1. Majumdar
2009
Corpus ID: 28568671
Introduction: Osteoarthritis (OA) is a complex disease that is mainly characterized by degradation of articular cartilage with an…
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2006
2006
Thrombin and NAD ( P ) H Oxidase
Aleksandr E. Vendrov
,
N. Madamanchi
,
Z. Hakim
,
Mauricio Rojas
,
M. Runge
2006
Corpus ID: 262008151
To characterize novel signaling pathways that underlie NAD(P)H oxidase–mediated signaling in atherosclerosis, we first examined…
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2006
2006
Regulation of aggrecanase-1 and aggrecanase-2 expressions by hypoxia and cytokines in rheumatoid fibroblast-like synoviocytes
Hyung Jinn Kim
,
E. Bae
,
+5 authors
E. Koh
2006
Corpus ID: 99817759
Background : While aggrecanases (aggrecanase-1 and aggrecanase-2) are substantially responsible for cartilage aggrecan breakdown…
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2005
2005
Chondrocyte response to in vitro mechanical injury and co-culture with joint capsule tissue
Jennifer H. Lee
2005
Corpus ID: 108857955
Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2005.
2002
2002
Pathobiology of the synovium in osteoarthritis
M. Smith
2002
Corpus ID: 72949943
The synovium is a vascularized soft tissue lining the capsule and intra-articular structures of diarthrodial joints. The synovial…
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