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ACY-738

 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Amyotrophic lateral sclerosis (ALS) is an aggressive and uniformly fatal degenerative disease of the motor nervous system. In… Expand
2019
2019
Multiple sclerosis (MS) is a complex disease characterized by autoimmune demyelination and progressive neurodegeneration… Expand
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2019
2019
Dysregulation of epigenetic mechanisms is emerging as a central event in neurodegenerative disorders, including amyotrophic… Expand
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2018
2018
We have demonstrated previously that histone deacetylase (HDAC6) expression is increased in animal models of systemic lupus… Expand
2016
2016
We sought to determine if a selective HDAC6 inhibitor (ACY-738) decreases disease in NZB/W mice. From 22 to 38weeks-of-age, mice… Expand
2016
2016
Charcot–Marie–Tooth disease (CMT) is the most common inherited peripheral neuropathy, with an estimated prevalence of 1 in 2500… Expand
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2015
2015
Current therapy for Alzheimer's disease (AD) focuses on delaying progression, illustrating the need for more effective… Expand
2015
2015
Prior studies have shown that pan-HDAC inhibition can decrease disease in lupus mice; however, the mechanisms(s) remain to be… Expand
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2015
2015
BACKGROUND Acetylation of heat shock protein 90 (Hsp90) regulates downstream hormone signaling via the glucocorticoid receptor… Expand
Highly Cited
2014
Highly Cited
2014
HDAC inhibitors have been reported to produce antidepressant and pro-cognitive effects in animal models, however, poor brain… Expand
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