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ACY-738

 
National Institutes of Health

Papers overview

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2019
2019
Dysregulation of epigenetic mechanisms is emerging as a central event in neurodegenerative disorders, including amyotrophic… Expand
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2019
2019
Autoantibody production by plasma cells (PCs) plays a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE). The… Expand
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2018
2018
We have demonstrated previously that histone deacetylase (HDAC6) expression is increased in animal models of systemic lupus… Expand
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2018
2018
Hepatic cystogenesis in polycystic liver disease (PLD) is associated with abnormalities in multiple cellular processes, including… Expand
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2016
2016
We sought to determine if a selective HDAC6 inhibitor (ACY-738) decreases disease in NZB/W mice. From 22 to 38weeks-of-age, mice… Expand
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2016
2016
Charcot–Marie–Tooth disease (CMT) is the most common inherited peripheral neuropathy, with an estimated prevalence of 1 in 2500… Expand
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2015
2015
Introduction Current therapy for Alzheimer's disease (AD) focuses on delaying progression, illustrating the need for more… Expand
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2015
2015
BACKGROUND Acetylation of heat shock protein 90 (Hsp90) regulates downstream hormone signaling via the glucocorticoid receptor… Expand
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2015
2015
Prior studies have shown that pan-HDAC inhibition can decrease disease in lupus mice; however, the mechanisms(s) remain to be… Expand
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Highly Cited
2014
Highly Cited
2014
HDAC inhibitors have been reported to produce antidepressant and pro-cognitive effects in animal models, however, poor brain… Expand
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