ACTN4 protein, human

Known as: F-Actin Cross-Linking Protein, Actinin Alpha4 Isoform, actinin, alpha 4, human 
Alpha-actinin-4 (911 aa, ~105 kDa) is encoded by the human ACTN4 gene. This protein plays a role in actin crosslinking.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1985-2018
051019852018

Papers overview

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Highly Cited
2008
Highly Cited
2008
The renin-angiotensin system (RAS) plays a critical role in the development of diabetic nephropathy, and blockade of the RAS is… (More)
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Highly Cited
2006
Highly Cited
2006
Although parietal podocytes along the Bowman's capsule have been described by electron microscopy in the normal human kidney… (More)
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2006
2006
Integrin-linked kinase (ILK) has been implicated in the pathogenesis of proteinuria and congenital nephrotic syndrome. However… (More)
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Highly Cited
2005
Highly Cited
2005
Mutations in the alpha-actinin-4 gene (ACTN4) cause an autosomal dominant form of focal segmental glomerulosclerosis (FSGS). A… (More)
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2005
2005
BACKGROUND The role of podocytes in human crescentic glomerulonephritis (GN) has been underestimated. This may be due to the… (More)
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Highly Cited
2002
Highly Cited
2002
The human kidneys filter 70 liters of blood plasma every day. The hallmark of almost all kidney diseases, whether acquired or… (More)
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Highly Cited
2002
Highly Cited
2002
Two PDZ domain-containing proteins, NHERF and E3KARP are necessary for cAMP-dependent inhibition of Na(+)/H(+) exchanger 3 (NHE3… (More)
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2002
2002
A number of cytoskeletal-associated proteins that are concentrated in focal contacts, namely ot-actinin, vinculin, talin, and… (More)
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Highly Cited
2001
Highly Cited
2001
We have identified an antigen recognized on a human large cell carcinoma by an autologous tumor-specific CTL clone that was… (More)
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Highly Cited
2000
Highly Cited
2000
Focal and segmental glomerulosclerosis (FSGS) is a common, non-specific renal lesion. Although it is often secondary to other… (More)
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