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ABT 627

Known as: (+)-A 127722, ABT-627, ABT627 
 
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Bone is the key metastatic site for prostate cancer. Endothelin 1 (ET-1) produced abundantly by prostate cancer cells binds to… Expand
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Highly Cited
2007
Highly Cited
2007
Endothelin (ET) receptor blockade delays the progression of diabetic nephropathy; however, the mechanism of this protection is… Expand
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Review
2006
Review
2006
Recent advances in the understanding of prostate cancer biology and its progression to bone metastasis have led to the… Expand
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Review
2005
Review
2005
Stroke patients have increased levels of endothelin-1 (ET-1), a strong vasoconstrictor, in their plasma or cerebrospinal fluid… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Angiotensin II-induced hypertension is associated with NAD(P)H oxidase-dependent superoxide production in the vessel… Expand
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Highly Cited
2003
Highly Cited
2003
PURPOSE To evaluate the efficacy and safety of atrasentan (ABT-627), an endothelin-A receptor antagonist, in the treatment of… Expand
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2002
2002
Endothelins (ETs), 21-amino-acid peptides involved in the pathogenesis of various diseases, bind to ET(A) and ET(B) receptors to… Expand
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Highly Cited
2001
Highly Cited
2001
A chronic reduction in uterine perfusion pressure in pregnant rats is associated with a significant elevation in mean arterial… Expand
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Highly Cited
2000
Highly Cited
2000
Tactile allodynia, the enhanced perception of pain in response to normally non-painful stimulation, represents a common… Expand
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2000
2000
++Endothelin (ET-1) acts as a potent vasoconstrictor in the human kidney, and this vasoconstriction could contribute to the… Expand
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