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ABT-288

 
National Institutes of Health

Papers overview

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2014
2014
A randomized study of H3 antagonist ABT-288 in mild-to-moderate Alzheimer's dementia.
BACKGROUND ABT-288, a highly selective histamine-3 receptor antagonist, demonstrated efficacy across several preclinical… Expand
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2014
2014
A randomized trial of the efficacy and safety of the H3 antagonist ABT-288 in cognitive impairment associated with schizophrenia.
INTRODUCTION ABT-288 is a highly potent histamine-3 receptor antagonist that has demonstrated pro-cognitive effects in… Expand
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2014
2014
The H3 antagonist ABT-288 is tolerated at significantly higher exposures in subjects with schizophrenia than in healthy volunteers.
AIMS ABT-288 is a potent and selective H3 receptor antagonist with procognitive effects in several preclinical models. In… Expand
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2014
2014
A Randomized Study of H 3 Antagonist ABT-288 in Mild-To-Moderate Alzheimer ’ s Dementia 1
  • George M. Haiga, Yili Pritchetta, +4 authors Robert Lenza
  • 2014
    • Corpus ID: 8485172
Background: ABT-288, a highly selective histamine-3 receptor antagonist, demonstrated efficacy across several preclinical… Expand
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2013
2013
Safety, tolerability and pharmacokinetics of the histamine H3 receptor antagonist, ABT-288, in healthy young adults and elderly volunteers.
AIM The objective of this work was to characterize the safety, tolerability and pharmacokinetics of ABT-288, a highly selective… Expand
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2013
2013
Assessment of the abuse liability of ABT-288, a novel histamine H3 receptor antagonist
RationaleHistamine H3 receptor antagonists, such as ABT-288, have been shown to possess cognitive-enhancing and wakefulness… Expand
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2012
2012
Pharmacological Properties and Procognitive Effects of ABT-288, a Potent and Selective Histamine H3 Receptor Antagonist
Blockade of the histamine H3 receptor (H3R) enhances central neurotransmitter release, making it an attractive target for the… Expand
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