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A349821

Known as: A-349821 
 
National Institutes of Health

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Broader (1)

Biphenyl Compounds

Papers overview

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2006
2006
Detection of multiple H3 receptor affinity states utilizing [3H]A‐349821, a novel, selective, non‐imidazole histamine H3 receptor inverse agonist radioligand
1 A‐349821 is a selective histamine H3 receptor antagonist/inverse agonist. Herein, binding of the novel non‐imidazole H3… Expand
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Highly Cited
2005
Highly Cited
2005
Evaluation of Histamine H 1-, H 2-, and H 3-Receptor Ligands at the Human Histamine H 4 Receptor : Identification of 4-Methylhistamine as the First Potent and Selective H 4 Receptor Agonist
The histamine H4 receptor (H4R) is involved in the chemotaxis of leukocytes and mast cells to sites of inflammation and is… Expand
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Review
2005
Review
2005
Efficacy in Cognition and Schizophrenia of a Potent and Selective Histamine H 3 Receptor Antagonist
Acute pharmacological blockade of central histamine H3 receptors (H3Rs) enhances arousal/attention in rodents. However, there is… Expand
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Highly Cited
2004
Highly Cited
2004
Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist.
Histamine H3 receptors regulate the release of a variety of central neurotransmitters involved in cognitive processes. A-349821… Expand
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2003
2003
Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists.
Novel 4'-[(NR1R2-1-yl)]-propoxy-biaryl-4-carboxamides were designed and synthesized. All compounds were tested for affinity at… Expand
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