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A 85380

Known as: A-85380 
National Institutes of Health

Related topics

Related topics

2 relations

Narrower (1)

A 159470

Broader (1)

Azetidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking.
CONTEXT Available levels of nicotinic acetylcholine receptors containing the beta(2) subunit (beta(2)*-nAChR) are higher in… 
Review
2006
Review
2006
A-85380: a pharmacological probe for the preclinical and clinical investigation of the alphabeta neuronal nicotinic acetylcholine receptor.
A-85380 [3-(2(s)-azetidinylmethoxy) pyridine] is a neuronal nicotinic acetylcholine receptor (nAChR) agonist that has been a… 
2004
2004
The Nicotinic Receptor in the Rat Pineal Gland Is an α3β4 Subtype
The rat pineal gland contains a high density of neuronal nicotinic acetylcholine receptors (nAChRs). We characterized the… 
Highly Cited
2002
Highly Cited
2002
Measuring nicotinic receptors with characteristics of alpha4beta2, alpha3beta2 and alpha3beta4 subtypes in rat tissues by autoradiography.
Comparison of [125I]epibatidine and 5-[125I]iodo-3-(2-azetidinylmethoxy)pyridine ([125I]A-85380) autoradiography showed evidence… 
2001
2001
A-85380 and epibatidine each interact with disparate spinal nicotinic receptor subtypes to achieve analgesia and nociception.
Nicotinic agonists, such as epibatidine (EPI) and A-85380, when administered systemically, elicit analgesia. Intrathecal EPI also… 
Review
2001
Review
2001
The therapeutic potential of nicotinic acetylcholine receptor agonists for pain control
Due to the limitations of currently available analgesics, a number of novel alternatives are currently under investigation… 
Highly Cited
2000
Highly Cited
2000
Reduced nicotinic receptor-mediated antinociception following in vivo antisense knock-down in rat
Highly Cited
1999
Highly Cited
1999
Imaging central nicotinic acetylcholine receptors in baboons with [18F]fluoro-A-85380.
UNLABELLED Central nicotinic acetylcholine receptors (nAChRs) have been implicated in learning-memory processes. Postmortem brain… 
Highly Cited
1998
Highly Cited
1998
Differences between the antinociceptive effects of the cholinergic channel activators A-85380 and (+/-)-epibatidine in rats.
(+/-)-Epibatidine (EPIB) and A-85380 are nicotinic acetylcholine receptor (nAChR) agonists that bind to the agonist ([3H]cytisine… 
Highly Cited
1998
Highly Cited
1998
2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling.
3-(2(S)-Azetidinylmethoxy)pyridine (A-85380) has been identified recently as a ligand with high affinity for nicotinic… 
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