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A 77636

Known as: A-77636, A77636 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (4)

AdamantaneAntiparkinson AgentsBenzopyransDopamine Agonists
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
The role of dopamine D1 receptor transmission in effort-related choice behavior: Effects of D1 agonists
Mesolimbic dopamine (DA), particularly in the nucleus accumbens, is a critical component of the brain circuitry involved in… Expand
Highly Cited
2005
Highly Cited
2005
Differential Activation of Adenylate Cyclase and Receptor Internalization by Novel Dopamine D1 Receptor Agonists
Structurally dissimilar dopamine D1 receptor agonists were compared with dopamine in their ability to activate adenylate cyclase… Expand
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Highly Cited
2001
Highly Cited
2001
Rewarding and locomotor-activating effects of direct dopamine receptor agonists are augmented by chronic food restriction in rats
Abstract. Rationale: Previous studies indicate that chronic food restriction augments the rewarding and motor-activating effects… Expand
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1999
1999
Actions of the D1 agonists A-77636 and A-86929 on locomotion and dyskinesia in MPTP-treated L-dopa-primed common marmosets
Abstract Common marmosets show parkinsonian motor deficits following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP… Expand
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Highly Cited
1998
Highly Cited
1998
Homologous desensitization of the D1A dopamine receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency.
The role of drug efficacy in agonist-induced desensitization was studied in C-6 glioma cells transfected with the monkey dopamine… Expand
Highly Cited
1996
Highly Cited
1996
Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping.
Compute-aided conformational analysis was used to characterize the agonist pharmacophore for D1 dopamine receptor recognition and… Expand
Highly Cited
1995
Highly Cited
1995
Chronic L‐DOPA administration induces dyskinesias in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐treated common marmoset (Callithrix jacchus)
Dyskinesias occur in the majority of patients with Parkinson's disease chronically treated with L‐DOPA and also occur in several… Expand
1994
1994
The potent and selective dopamine D1 receptor agonist A-77636 increases cortical and hippocampal acetylcholine release in the rat.
The effects of systemic administration of the full dopamine D1 receptor agonist A-77636 on acetylcholine release in rat frontal… Expand
Highly Cited
1993
Highly Cited
1993
Differential effect of selective D-1 and D-2 dopamine receptor agonists on levodopa-induced dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- exposed monkeys.
The motor effects of selective D-1 dopamine receptor stimulation in Parkinson's disease have been explored in a limited number of… Expand
Highly Cited
1992
Highly Cited
1992
A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets.
A-77636, ((1R,3S) 3-(1'-adamantyl)-1-aminomethyl-3,4-dihydro-5,6-dihydroxy-1H-2-benz opyran hydrochloride), is a selective… Expand
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