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A 74273

Known as: A-74273, A74273 
National Institutes of Health

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2 relations

Broader (2)

AmidesMorpholines

Papers overview

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1993
1993
Cardiovascular Effects and Hemodynamic Mechanism of Action of the Novel, Nonpeptidic Renin Inhibitor A‐74273 in Dogs
Summary A-74273 is a nonpeptidic, potent inhibitor of human and canine renin (IC50 = 3.1 and 43 nM, respectively, in plasma at pH… 
1993
1993
Effects of High Doses of A‐74273, a Novel Nonpeptidic and Orally Bioavailable Renin Inhibitor
Previous studies with peptidic renin inhibitors have shown that high intravenous (i.v) doses can induce unexpectedly large… 
1992
1992
C-terminal modifications of nonpeptide renin inhibitors: improved oral bioavailability via modification of physicochemical properties.
We describe the development of a series of soluble, potent, and bioavailable nonpeptide renin inhibitors. These inhibitors… 
1992
1992
Discovery of a well-absorbed, efficacious renin inhibitor, A-74273.
The development of orally active renin inhibitors has been plagued by limited bioavailability in animals and humans. A-74273 is a… 
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