A 74273

Known as: A-74273, A74273 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1992-1994
01219921994

Papers overview

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1994
1994
The metabolism and disposition of [14C]A-74273--a potent, orally active renin inhibitor--were investigated in beagle dogs and… (More)
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1994
1994
The aim of this study was the discovery of nonpeptide renin inhibitors with much improved oral absorption, bioavailability, and… (More)
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1993
1993
A-74273 is a nonpeptidic, potent inhibitor of human and canine renin (IC50 = 3.1 and 43 nM, respectively, in plasma at pH 7.4… (More)
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1993
1993
Previous studies with peptidic renin inhibitors have shown that high intravenous (i.v.) doses can induce unexpectedly large… (More)
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1992
1992
The development of orally active renin inhibitors has been plagued by limited bioavailability in animals and humans. A-74273 is a… (More)
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1992
1992
We describe the development of a series of soluble, potent, and bioavailable nonpeptide renin inhibitors. These inhibitors… (More)
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