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A 63162

Known as: A-63162 
National Institutes of Health

Papers overview

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1993
1993
Role of eicosanoids in hyperpnea-induced airway responses in guinea pigs.
Guinea pigs mechanically hyperventilated with dry gas exhibit hyperpnea-induced bronchoconstriction (HIB) and hyperpnea-induced… 
1993
1993
Inhibition of human mononuclear cell proliferation, interleukin synthesis, mRNA for IL‐2, IL‐6, and leukotriene B4 synthesis by a lipoxygenase inhibitor
Human peripheral blood mononuclear cells (PBMCs) were cultured in vitro with various stimuli and in the presence or absence of a… 
1993
1993
Effect of mode of activation of human eosinophils on tracheal smooth muscle contraction in guinea pigs.
We studied the relationship between mode of activation of isolated human eosinophils and in situ responsiveness in isolated… 
1993
1993
Effects of prostaglandin of E, F and I series, leukotriene C and platelet activating factor on amylase release from isolated rat pancreatic acini.
Exogenous eicosanoids were reported to affect pancreatic secretion, but it is unknown whether this effects is mediated by the… 
1992
1992
Mast cells contribute to fibrin deposition in reverse passive Arthus reaction in mouse skin
The activation of the clotting system is an important process during inflammation to contain the injury and initiate tissue… 
1992
1992
Inhibition of equine mononuclear cell proliferation and leukotriene B4 synthesis by a specific 5-lipoxygenase inhibitor, A-63162.
The lipoxygenase metabolites of arachidonic acid have an important role in lymphocyte activation. We used a specific 5… 
1992
1992
Mast cells enhance the antibody-mediated injury of skin basement membrane in mice.
Immunologic basement membrane injury occurs in certain human diseases. We investigated the role of mast cells in the initiation… 
1992
1992
Leukotriene formation by mouse connective tissue mast cells.
Stimulation of peritoneal cells from BALB/c, CBA/J or WBB6F1(-)+/+ mice with IgE/antigen caused the release of mast cell granules… 
1992
1992
Characterization of a direct effect of phorbol myristate acetate on human neutrophil cell membrane using 31D8 monoclonal antibody
We found that 4‐β‐phorbol 12‐myristate 13‐acetate (PMA) caused decreased expression of the polymorphonuclear neutrophil (PMN… 
1991
1991
Effect of A-63162 on lymphocyte proliferation, IL-2 production, mRNA for Il-2 and LTB sub 4 production from human mononuclear cells
Lipoxygenase metabolites of arachidonic acid have diversified effects on human lymphocytes. In the present investigation, the… 
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