A/G-Specific Adenine DNA Glycosylase

Known as: MUTYH, EC 3.2.2.-, hMYH 
A/G-specific adenine DNA glycosylase protein (546 aa, ~60 kDa) is encoded by the MUTYH gene. This nuclear enzyme plays a role in mismatch repair via… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Reactive oxygen species (ROS) interact with DNA, frequently generating highly mutagenic 7,8-dihydro-8-oxoguanine (8-oxo-G… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE In the central nervous system (CNS), increased mitochondrial DNA (mtDNA) damage is associated with aging and may underlie… (More)
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Highly Cited
2004
Highly Cited
2004
The genomes of aerobic organisms suffer chronic oxidation of guanine to the genotoxic product 8-oxoguanine (oxoG). Replicative… (More)
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Highly Cited
2002
Highly Cited
2002
Adenines mismatched with guanines or 7,8-dihydro-8-oxo-deoxyguanines that arise through DNA replication errors can be repaired by… (More)
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Highly Cited
2001
Highly Cited
2001
The human MutY homolog (hMYH) is a DNA glycosylase involved in the removal of adenines or 2-hydroxyadenines misincorporated with… (More)
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Review
2001
Review
2001
In mammalian cells, more than one genome has to be maintained throughout the entire life of the cell, one in the nucleus and the… (More)
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Highly Cited
2001
Highly Cited
2001
The human MutY homolog, hMYH, is an adenine-specific DNA glycosylase that removes adenines or 2-hydroxyadenines mispaired with… (More)
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Highly Cited
1999
Highly Cited
1999
The post-replicative adenine:8-oxo-7,8-dihydroguanine (GO) mismatch is crucial for G:C to T:A transversion. This mismatch is… (More)
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Highly Cited
1998
Highly Cited
1998
Oxidative damage to mitochondrial DNA has been implicated in human degenerative diseases and aging. Although removal of oxidative… (More)
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Highly Cited
1996
Highly Cited
1996
We have cloned the human mutY gene (hMYH) from both genomic and cDNA libraries. The human gene contains 15 introns and is 7.1 kb… (More)
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