8-oxoguanine

Known as: 8-Oxo-7,8-Dihydroguanine, 7,8-Dihydro-8-Oxoguanine, 2-Aminopurine-6,8-Diol 
A derivative of the purine nucleoside guanine that is found in DNA that has been damaged due to exposure to reactive oxygen species or ionizing… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
The human 8-oxoguanine-DNA glycosylase 1 (OGG1) is the major DNA glycosylase responsible for repair of 7,8-dihydro-8-oxoguanine… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
Is this relevant?
Highly Cited
2001
Highly Cited
2001
8-Oxoguanine-DNA glycosylase 1 (OGG1), with intrinsic AP lyase activity, is the major enzyme for repairing 7,8-dihydro-8… (More)
  • figure 1
  • figure 2
  • figure 5
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Mitochondria are not only the major site for generation of reactive oxygen species, but also one of the main targets of oxidative… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Spontaneous oxidation of guanine residues in DNA generates 8-oxoguanine (oxoG). By mispairing with adenine during replication… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
We identified seven alternatively spliced forms of human 8-oxoguanine DNA glycosylase (OGG1) mRNAs, classified into two types… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
The repair pathways involved in the removal of 8-oxo-7, 8-dihydroguanine (8-oxoguanine) in DNA by mammalian cell extracts have… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Oxidative DNA damage is generated by reactive oxygen species. The mutagenic base, 8-oxoguanine, formed by this process, is… (More)
Is this relevant?
Review
1993
Review
1993
The presence of reactive oxygen species in cells ensures that the oxidatively damaged base 8-oxoguanine will be generated at high… (More)
Is this relevant?
Highly Cited
1992
Highly Cited
1992
Mutations caused by oxidative DNA damage may contribute to human disease. A major product of that damage is 8-hydroxyguanine… (More)
Is this relevant?
Highly Cited
1991
Highly Cited
1991
Substrate specificities of FPG protein (also known as formamidopyrimidine DNA glycosylase) and 8-hydroxyguanine endonuclease were… (More)
Is this relevant?