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8-oxo-7-hydrodeoxyguanosine

Known as: 7,8-dihydro-8-oxo-2'-deoxyguanosine, 8-Oxo-7,8-dihydro-2'-deoxyguanosine, 8-OH-dG 
A major spontaneous oxidized derivative of 2'-deoxyguanosine and a biomarker of oxidative DNA damage. 8-hydroxy-2'-deoxyguanosine (8-oxo-dG) is… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Deoxyguanosine
analogs & derivatives

Papers overview

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Highly Cited
2004
Highly Cited
2004
Comparison of analyses of urinary 8-hydroxy-2'-deoxyguanosine by isotope-dilution liquid chromatography with electrospray tandem mass spectrometry and by enzyme-linked immunosorbent assay.
A highly sensitive and selective method, using isotope-dilution liquid chromatography with tandem mass spectrometry (LC/MS/MS… 
Highly Cited
2002
Highly Cited
2002
Distinct spectrum of mutations induced by crocidolite asbestos: clue for 8-hydroxydeoxyguanosine-dependent mutagenesis in vivo.
DNA damage due to reactive oxygen or nitrogen species is proposed to be involved in the molecular mechanism of asbestos-induced… 
Highly Cited
2001
Highly Cited
2001
The alterations of N-Methyl-d-aspartate receptor expressions and oxidative DNA damage in the CA1 area at the early time after ischemia-reperfusion insult
Highly Cited
2000
Highly Cited
2000
Removal of hydantoin products of 8-oxoguanine oxidation by the Escherichia coli DNA repair enzyme, FPG.
An intriguing feature of 7,8-dihydro-8-oxo-2'-deoxyguanosine (OG) is that it is highly reactive toward further oxidation. Indeed… 
Highly Cited
2000
Highly Cited
2000
Fast quantification of the urinary marker of oxidative stress 8-hydroxy-2'-deoxyguanosine using solid-phase extraction and high-performance liquid chromatography with triple-stage quadrupole mass…
Highly Cited
1998
Highly Cited
1998
Superoxide formation and DNA damage induced by a fragrant furanone in the presence of copper(II).
Highly Cited
1994
Highly Cited
1994
Evaluation of 8-hydroxydeoxyguanosine, a typical oxidative DNA damage, in human leukocytes.
8-Hydroxydeoxyguanosine (8-OHdG) is a typical form of oxidative DNA damage which causes mutation in vitro and in vivo. We… 
Highly Cited
1983
Highly Cited
1983
Dependence of DNA helix flexibility on base composition
We have used triplet anisotropy decay techniques to study the flexibility of synthetic DNA fragments with different base pair… 
Highly Cited
1981
Highly Cited
1981
Studies of nucleotide conformations and interactions. The relative stabilities of double‐helical B‐DNA sequence isomers
We present the results of molecular‐mechanics studies on base‐paired dinucleoside phosphates and hexanucleoside pentaphosphates… 
Highly Cited
1977
Highly Cited
1977
Detection of carcinogen–DNA adducts by radioimmunoassay
COVALENT binding of carcinogen to nucleic acids is believed to be an essential component of the carcinogenic process1, so it is… 
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