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8-methyladenosine

Known as: Adenosine, 8-methyl- 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2016
01219892016

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2 relations

Broader (1)

Adenosine
analogs & derivatives

Related mentions per year

Related mentions per year

1937-2018
19401960198020002020
8-methyladenosine
Adenosine
analogs & derivatives

Papers overview

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2016
2016
Doxifluridine-conjugated 2-5A analog shows strong RNase L activation ability and tumor suppressive effect.
RNase L is activated by 2',5'-oligoadenylates (2-5A) at subnanomolar levels to cleave single-stranded RNA. We previously reported… (More)
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Highly Cited
2011
Highly Cited
2011
The RNA modification database, RNAMDB: 2011 update
Since its inception in 1994, The RNA Modification Database (RNAMDB, http://rna-mdb.cas.albany.edu/RNAmods/) has served as a focal… (More)
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2010
2010
5'-O-dephosphorylated 2',5'-oligoadenylate (2-5A) with 8-methyladenosine at the 2'-terminus activates human RNase L.
Human ribonuclease L (RNase L), an interferon-induced endoribonuclease, becomes enzymatically active after binding to 2-5A. The 5… (More)
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2009
2009
Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria.
The Cfr methyltransferase confers combined resistance to five different classes of antibiotics that bind to the peptidyl… (More)
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2009
2009
Introduction of 8-methyladenosine into 2', 5'-oligoadenylate (2-5A) 2'-terminus induces dramatic shift in binding site of RNase L.
The 2',5'-oligoadenylate (2-5A) system is an interferon (IFN)-regulated RNA decay pathway that provides innate immunity against… (More)
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Review
2004
Review
2004
Therapeutic potential of nucleoside/nucleotide analogues against poxvirus infections.
Several nucleoside and nucleotide analogues have been identified as potent antiviral agents with convincing activity against… (More)
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2003
2003
Synthesis of antisense oligonucleotides carrying modified 2-5A molecules at their 5'-termini and their properties.
The synthesis of 8-methyladenosine-substituted 2-5A tetramers with hydroxyalkyl groups at the 5'-phosphates and the corresponding… (More)
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1993
1993
Antiviral activity of C-alkylated purine nucleosides obtained by cross-coupling with tetraalkyltin reagents.
2-, 6-, And 8-alkylated (methyl, ethyl, and vinyl) adenosine analogues were synthesized by a palladium-catalyzed cross-coupling… (More)
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1991
1991
8-Methyladenosine-substituted analogues of 2-5A: synthesis and their biological activities.
8-Methyladenosine-substituted analogues of 2-5A, p5'A2'p5'A2'p5'(me8A), p5'A2'p5'(me8A)2'p5'(me8A), p5'(me8A)2'p5'(me8A)2'p5… (More)
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1989
1989
8-Methyladenosine-substituted analogs of 2-5A: synthesis and properties.
Four 8-methyladenosine-substituted analogs of 2-5A were obtained by a synthesis which involved a modification of the lead ion… (More)
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