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8-hydroxyfuranocoumarin 8-O-methyltransferase activity

Known as: S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase activity, xanthotoxol methyltransferase activity, furanocoumarin 8-O-methyl-transferase activity 
Catalysis of the reaction: S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin. Xanthotoxol is also known as 8… Expand
National Institutes of Health

Papers overview

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2018
2018
Biotransformation of furanocoumarins by fungi: preparation of imperation analogs
Abstract Imperation analogs have the furanocoumarin skeleton, with the isopentenyl group, which displayed significant… Expand
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2017
2017
Modulation of Multidrug Resistance Gene Expression by Coumarin Derivatives in Human Leukemic Cells
The presence of multidrug resistance (MDR) in tumor cells is considered as the major cause of failure of cancer chemotherapy. The… Expand
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2017
2017
Design, Synthesis and Antifungal Activity of Psoralen Derivatives
A series of linear furanocoumarins with different substituents have been designed and synthesized. Their structures were… Expand
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2014
2014
Furanocoumarins Are a Novel Class of Modulators for the Transient Receptor Potential Vanilloid Type 1 (TRPV1) Channel*
Background: Furanocoumarin imperatorin is a major active component of Angelica dahurica root extracts exhibiting analgesic… Expand
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2014
2014
Matrix solid-phase dispersion versus ultrasound assisted extraction with solid-phase extraction in the HPLC analysis of furanocoumarins from fruits of Archangelica officinalis Hoffm
In this study an efficient matrix solid-phase dispersion (MSPD) method for the simultaneous HPLC analysis of furanocoumarins from… Expand
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2008
2008
Development of a Fission Yeast-Based High-Throughput Screen to Identify Chemical Regulators of cAMP Phosphodiesterases
Cyclic nucleotide phosphodiesterases (PDEs) comprise a superfamily of enzymes that serve as drug targets in many human diseases… Expand
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2006
2006
Synthesis of 8-geranyloxypsoralen analogues and their evaluation as inhibitors of CYP3A4.
Furanocoumarins have been shown to inhibit CYP3A4 in vitro with varying degrees of potency. In this study, we report the effects… Expand
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1990
1990
Metabolism and excretion of the furanocoumarin xanthotoxin by parsnip webworm,Depressaria pastinacella
The parsnip webworm,Depressaria pastinacella, feeds on plants containing high concentrations of furanocoumarins. compounds toxic… Expand
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1986
1986
Inactivation and mutagenesis by phototoxins usingEscherichia coli strains differing in sensitivity to near- and far-ultraviolet light
FourEscherichia coli strains carrying all the possible combinations of genes controlling sensitivity to near-UV (NUV;nur… Expand
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