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8-chloro-cyclic adenosine monophosphate

Known as: 8-chloroadenosine 3',5'-cyclic monophosphate, cAMP, 8-Chloro Cyclic AMP 
An antimetabolite and a chlorine derivative of the intracellular secondary messenger, cyclic adenosine 3,5-monophosphate (cAMP), with potential… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (3)

8-Bromo Cyclic Adenosine MonophosphateAntineoplastic AgentsImmunologic Factors
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Papers overview

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Highly Cited
2007
Highly Cited
2007
of in The Role of the in the A Molecular for Generating cAMP and cGMP Signaling Cross-Talk Role of Phosphodiesterases and Implications for Cardiac Pathophysiology
—Cyclic nucleotide phosphodiesterases regulate cAMP-mediated signaling by controlling intracellular cAMP content. The cAMP… 
Highly Cited
1986
Highly Cited
1986
Involvement of protein kinase C in the regulation of adrenocorticotropin release from rat anterior pituitary cells.
The involvement of protein kinase C in normal corticotroph function was studied by analysis of the effects of the phorbol ester… 
Highly Cited
1984
Highly Cited
1984
Phosphorylation in sealed rod outer segments: effects of cyclic nucleotides.
Rod outer segments (ROS) from rat were purified on Percoll gradients. These ROS had intact plasma membranes since they were… 
Highly Cited
1981
Highly Cited
1981
Inhibitory Action of Adenosine on Histamine‐ and Dopamine‐Stimulated Cardiac Contractility and Adenylate Cyclase in Guinea Pigs
Infusion of adenosine into the coronary arteries of isolated guinea pig hearts produced a dose-dependent inhibition of cardiac… 
Highly Cited
1981
Highly Cited
1981
Mobilization of a common source of smooth muscle Ca2+ by norepinephrine and methylxanthines.
The ability of norepinephrine (NE), caffeine (CAF), theophylline (THEO), dinitrophenol (DNP), and potassium (high K) to mobilize… 
Highly Cited
1980
Highly Cited
1980
Immunological distinction between guanosine 3':5'-monophosphate-dependent and adenosine 3':5'-monophosphate-dependent protein kinases.
A guanosine 3':5'-monophosphate (cGMP)-dependent protein kinase was purified from bovine lung using 8-(6-aminohexylamino)-cAMP… 
Highly Cited
1980
Highly Cited
1980
The role of agonists that activate adenylate cyclase in the control of cAMP metabolism and enzyme release by human polymorphonuclear leukocytes.
An inverse relationship between cAMP content and effector function is ascribed generally to immune and inflammatory cells… 
Highly Cited
1980
Highly Cited
1980
A cAMP-dependent phosphorylated motility protein in bovine epididymal sperm.
A putative cAMP-dependent protein kinase substrate associated with the cAMP stimulation of bovine sperm motility has been… 
Highly Cited
1979
Highly Cited
1979
Adenosine receptor on human basophils: modulation of histamine release.
Adenosine, at physiologic concentrations, inhibits in vitro IgE-mediated human basophil histamine release in a dose-dependent… 
Highly Cited
1978
Highly Cited
1978
The modulator-dependent protein kinase. A multifunctional protein kinase activatable by the Ca2+-dependent modulator protein of the cyclic nucleotide system.
A protein kinase which depends on the simultaneous presence of Ca2+ and the modulator protein for its histone phosphorylation…