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7-ornithine-tyrocidine A

Known as: Orn-TA, Tyrocidine A, 10-L-ornithine-, dihydrochloride 
National Institutes of Health

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2 relations

Broader (1)

Tyrocidine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Tyrocidine A interactions with saccharides investigated by CD and NMR spectroscopies
Tyrocidines are a family of cyclic decapeptides produced by the soil bacterium, Brevibacillus parabrevis. These antibiotic… Expand
2017
2017
Stabilizing the monomeric amyloid-β peptide by tyrocidine A prevents and reverses amyloidogenesis without the accumulation of oligomers.
Amyloid-β (Aβ) oligomers are causative agents triggering AD pathogenesis, but their elimination remains challenging. We herein… Expand
2017
2017
Tyrocidine A Analogues Bearing the Planar d-Phe-2-Abz Turn Motif: How Conformation Impacts Bioactivity.
The d-Phe-Pro β-turn of the cyclic β-hairpin antimicrobial decapeptide tyrocidine A, (Tyrc A) was substituted with the d-Phe-2… Expand
2015
2015
Synthesis and antibacterial activities of novel tyrocidine A glycosylated derivatives towards multidrug‐resistant pathogens
Glycosylation can have a multifaceted impact on the properties and functions of peptides and plays a critical role in interacting… Expand
2014
2014
The high resolution structure of tyrocidine A reveals an amphipathic dimer.
Tyrocidine A, one of the first antibiotics ever to be discovered, is a cyclic decapeptide that binds to membranes of target… Expand
2012
2012
In situ potentiometric method to evaluate bacterial outer membrane-permeabilizing ability of drugs: example using antiprotozoal diamidines.
We introduced a new assay system, combining tyrocidine A and a K(+)-selective electrode, to evaluate the bacterial outer membrane… Expand
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2010
2010
The reversible macrocyclization of Tyrocidine A aldehyde: a hemiaminal reminiscent of the tetrahedral intermediate of macrolactamization.
In spite of the important role of peptide macrocyclizations for the generation of conformationally constrained biological ligands… Expand
2007
2007
Development of Tyrocidine A analogues with improved antibacterial activity.
The development of new antibacterial therapeutic agents capable of halting microbial resistance is a chief pursuit in clinical… Expand
2002
2002
Synthesis of tyrocidine A and its analogues by spontaneous cyclization in aqueous solution.
[reaction: see text] Head-to-tail cyclization of peptides is a multistep process involving tedious C-terminal activation and side… Expand
1979
1979
Tyrocidine A: crystal growth and preliminary x-ray diffraction data.
Tyrocidine A was crystallized from 2-methyl-2,4-pentanediol and water, or methanol, to yield crystals that are large enough for X… Expand
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