7-ornithine-tyrocidine A

Tyrocidines are a family of cyclic decapeptides produced by the soil bacterium, Brevibacillus parabrevis. These antibiotic… Expand

Amyloid-β (Aβ) oligomers are causative agents triggering AD pathogenesis, but their elimination remains challenging. We herein… Expand

The d-Phe-Pro β-turn of the cyclic β-hairpin antimicrobial decapeptide tyrocidine A, (Tyrc A) was substituted with the d-Phe-2… Expand

Glycosylation can have a multifaceted impact on the properties and functions of peptides and plays a critical role in interacting… Expand

Tyrocidine A, one of the first antibiotics ever to be discovered, is a cyclic decapeptide that binds to membranes of target… Expand

We introduced a new assay system, combining tyrocidine A and a K(+)-selective electrode, to evaluate the bacterial outer membrane… Expand

In spite of the important role of peptide macrocyclizations for the generation of conformationally constrained biological ligands… Expand

The development of new antibacterial therapeutic agents capable of halting microbial resistance is a chief pursuit in clinical… Expand

[reaction: see text] Head-to-tail cyclization of peptides is a multistep process involving tedious C-terminal activation and side… Expand

Tyrocidine A was crystallized from 2-methyl-2,4-pentanediol and water, or methanol, to yield crystals that are large enough for X… Expand