7-ketocholesterol

Known as: 3 beta-hydroxycholest-5-en-7-one, 7-oxocholesterol, 3beta-hydroxy-5-cholestene-7-one 
 
National Institutes of Health

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Highly Cited
2007
Highly Cited
2007
Oxidized sterols consumed in the diet or formed on low-density lipoprotein (LDL) are toxic to endothelial cells and macrophages… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND The endoplasmic reticulum (ER) responds to various stresses by upregulation of ER chaperones, but prolonged ER stress… (More)
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Highly Cited
2004
Highly Cited
2004
The mechanisms involved in the cytotoxic action of oxysterols in the pathogenesis of atherosclerosis still remain poorly… (More)
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Highly Cited
2004
Highly Cited
2004
Abstract7-Ketocholesterol is a component of oxidized LDL, which plays a central role in atherosclerosis. It is a potent inducer… (More)
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2004
2004
OBJECTIVE Oxysterols such as 7-ketocholesterol (7-KC) are important mediators of cell death in atherosclerosis. Therefore, in… (More)
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Highly Cited
1999
Highly Cited
1999
Oxidized low density lipoproteins (LDLs) play a central role in atherosclerosis, and their toxicity is due, at least in part, to… (More)
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Highly Cited
1997
Highly Cited
1997
7-Hydroperoxycholesterols (7OOHs) are intermediates in cholesterol oxidation and potential cytotoxins. A normal-phase HPLC method… (More)
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1996
1996
In the multifunctional pathogens of atherosclerosis, oxidatively modified low density lipoprotein (LDL) plays a central role in… (More)
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1994
1994
The cytotoxicity of oxidized low-density lipoprotein (Ox-LDL) to arterial smooth muscle cells (SMCs) may contribute to… (More)
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Highly Cited
1974
Highly Cited
1974
Of 47 steroid compounds tested for their ability to suppress 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured… (More)
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