7-hydroxymethotrexate

Known as: 7-OH-methotrexate, N-(4-(((2,4-diamino-1,7-dihydro-7-oxo-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamic acid 
 
National Institutes of Health

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Highly Cited
2004
Highly Cited
2004
The antifolate drug methotrexate (MTX) is transported by breast cancer resistance protein (BCRP; ABCG2) and multidrug resistance… (More)
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1996
1996
To elucidate mechanisms for methotrexate (MTX)-induced renal and hepatic toxicity, we investigated the acute effects of bolus… (More)
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1994
1994
7-Hydroxymethotrexate (7-OH-MTX) is the major and, frequently the only, pteridine metabolite found in bone-marrow aspirates of… (More)
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1989
1989
The pharmacokinetics of methotrexate (MTX) and 7-hydroxymethotrexate (7-OH-MTX) in bile, urine, and serum was studied in rats in… (More)
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1984
1984
7-Hydroxymethotrexate, an important metabolite of methotrexate, is a substrate for folylpolyglutamate synthetase (FPGS) isolated… (More)
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1984
1984
The synthesis of poly-gamma-glutamyl derivatives of 7-hydroxymethotrexate (7-OH-4-NH2-10-CH3-pteroyl-glutamic acid (PteGlu1] was… (More)
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1983
1983
The metabolism of methotrexate in rabbits was investigated following 6 hr of infusion with [3',5',7-(3)H]methotrexate (50 mg/kg… (More)
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1983
1983
The intracellular synthesis of polyglutamyl derivatives of both methotrexate (4-amino-N-10-methylpteroylglutamic acid) and 7… (More)
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1982
1982
The pharmacokinetics of methotrexate (MXT) and 7-hydroxymethotrexate (7-OH-MTX) has been studied in seven patients treated for… (More)
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Highly Cited
1976
Highly Cited
1976
Human subjects and rhesus monkeys receiving the antitumor agent methotrexate at the high dose levels recently introduced into… (More)
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