7-dehydropregnenolone
National Institutes of Health
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We have previously described new pathways of vitamin D3 activation by CYP11A1 to produce a variety of metabolites including 20(OH…
BackgroundCholesterol, the precursor of all steroid hormones, is the most abundant steroid in vertebrates and exhibits highly…
Novel metabolic pathways initiated by the enzymatic action of CYP11A1 on 7DHC (7-dehydrocholesterol), ergosterol, vitamins D3 and…
CYP17 (steroid 17α-hydroxylase/17,20-lyase) is a key enzyme in steroid hormone biosynthesis. It catalyzes two independent…
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The active form of vitamin D, 1,25(OH)2D3, has a number of desirable properties in addition to its…
Background Cytochrome P450scc metabolizes vitamin D3 to 20-hydroxyvitamin D3 (20(OH)D3) and 20,23(OH)2D3, as well as 1…
Since P450scc transforms 7-dehydrocholesterol (7DHC) to 7-dehydropregnenolone (7DHP) in vitro, we investigated sequential 7DHC…
Following up on our previous findings that the skin possesses steroidogenic activity from progesterone, we now show widespread…
Metabolites of vitamin D3 (D3) (cholecalciferol) are recognized as enzymatically formed chemicals in humans that can influence a…