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7-dehydropregnenolone
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (1)
Pregnenolone
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
Photoprotective Properties of Vitamin D and Lumisterol Hydroxyderivatives
A. Slominski
,
Anyamanee Chaiprasongsuk
,
+16 authors
R. Tuckey
Cell Biochemistry and Biophysics
2020
Corpus ID: 218772413
We have previously described new pathways of vitamin D3 activation by CYP11A1 to produce a variety of metabolites including 20(OH…
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2015
2015
Functionalized PHB granules provide the basis for the efficient side-chain cleavage of cholesterol and analogs in recombinant Bacillus megaterium
A. Gerber
,
Michael Kleser
,
Rebekka Biedendieck
,
R. Bernhardt
,
F. Hannemann
Microbial Cell Factories
2015
Corpus ID: 2857503
BackgroundCholesterol, the precursor of all steroid hormones, is the most abundant steroid in vertebrates and exhibits highly…
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Review
2013
Review
2013
Novel vitamin D photoproducts and their precursors in the skin
A. Slominski
,
Tae-Kang Kim
,
+9 authors
R. Tuckey
Dermato-endocrinology
2013
Corpus ID: 5869223
Novel metabolic pathways initiated by the enzymatic action of CYP11A1 on 7DHC (7-dehydrocholesterol), ergosterol, vitamins D3 and…
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2013
2013
Role of microsomal steroid hydroxylases in Δ7-steroid biosynthesis
T. Sushko
,
A. Gilep
,
A. Yantsevich
,
S. Usanov
Biochemistry (Moscow)
2013
Corpus ID: 15718405
CYP17 (steroid 17α-hydroxylase/17,20-lyase) is a key enzyme in steroid hormone biosynthesis. It catalyzes two independent…
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Highly Cited
2012
Highly Cited
2012
Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes.
A. Slominski
,
Tae-Kang Kim
,
+6 authors
R. Tuckey
The international journal of biochemistry & cell…
2012
Corpus ID: 205989012
The discovery that 7-dehydrocholesterol (7DHC) is an excellent substrate for cytochrome P450scc (CYP11A1) opens up new…
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2011
2011
Vitamin D analogs 17,20S(OH)2pD and 17,20R(OH)2pD are noncalcemic and exhibit antifibrotic activity.
A. Slominski
,
W. Li
,
+9 authors
A. Postlethwaite
The Journal of investigative dermatology
2011
Corpus ID: 4783782
LETTER TO THE EDITOR The active form of vitamin D, 1,25(OH)2D3, has a number of desirable properties in addition to its…
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Highly Cited
2010
Highly Cited
2010
Products of Vitamin D3 or 7-Dehydrocholesterol Metabolism by Cytochrome P450scc Show Anti-Leukemia Effects, Having Low or Absent Calcemic Activity
A. Slominski
,
Z. Janjetovic
,
+10 authors
M. Holick
PloS one
2010
Corpus ID: 11568054
Background Cytochrome P450scc metabolizes vitamin D3 to 20-hydroxyvitamin D3 (20(OH)D3) and 20,23(OH)2D3, as well as 1…
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Highly Cited
2009
Highly Cited
2009
Sequential Metabolism of 7-Dehydrocholesterol to Steroidal 5,7-Dienes in Adrenal Glands and Its Biological Implication in the Skin
A. Slominski
,
M. Żmijewski
,
+5 authors
R. Tuckey
PloS one
2009
Corpus ID: 7035527
Since P450scc transforms 7-dehydrocholesterol (7DHC) to 7-dehydropregnenolone (7DHP) in vitro, we investigated sequential 7DHC…
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Highly Cited
2004
Highly Cited
2004
A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin.
A. Slominski
,
J. Zjawiony
,
+7 authors
Robert C Tuckey
European journal of biochemistry
2004
Corpus ID: 710858
Following up on our previous findings that the skin possesses steroidogenic activity from progesterone, we now show widespread…
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Highly Cited
2003
Highly Cited
2003
A pathway for the metabolism of vitamin D3: Unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1)
O. Guryev
,
R. A. Carvalho
,
S. Usanov
,
A. Gilep
,
R. Estabrook
Proceedings of the National Academy of Sciences…
2003
Corpus ID: 20671051
Metabolites of vitamin D3 (D3) (cholecalciferol) are recognized as enzymatically formed chemicals in humans that can influence a…
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