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7-dehydropregnenolone

 
National Institutes of Health

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Broader (1)

Pregnenolone
analogs & derivatives

Papers overview

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Review
2020
Review
2020
Photoprotective Properties of Vitamin D and Lumisterol Hydroxyderivatives
We have previously described new pathways of vitamin D3 activation by CYP11A1 to produce a variety of metabolites including 20(OH… Expand
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2015
2015
Functionalized PHB granules provide the basis for the efficient side-chain cleavage of cholesterol and analogs in recombinant Bacillus megaterium
BackgroundCholesterol, the precursor of all steroid hormones, is the most abundant steroid in vertebrates and exhibits highly… Expand
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Review
2013
Review
2013
Novel vitamin D photoproducts and their precursors in the skin
Novel metabolic pathways initiated by the enzymatic action of CYP11A1 on 7DHC (7-dehydrocholesterol), ergosterol, vitamins D3 and… Expand
2013
2013
Role of microsomal steroid hydroxylases in Δ7-steroid biosynthesis
CYP17 (steroid 17α-hydroxylase/17,20-lyase) is a key enzyme in steroid hormone biosynthesis. It catalyzes two independent… Expand
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Highly Cited
2012
Highly Cited
2012
Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes.
The discovery that 7-dehydrocholesterol (7DHC) is an excellent substrate for cytochrome P450scc (CYP11A1) opens up new… Expand
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2011
2011
Vitamin D analogs 17,20S(OH)2pD and 17,20R(OH)2pD are noncalcemic and exhibit antifibrotic activity.
LETTER TO THE EDITOR The active form of vitamin D, 1,25(OH)2D3, has a number of desirable properties in addition to its… Expand
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Highly Cited
2010
Highly Cited
2010
Products of Vitamin D3 or 7-Dehydrocholesterol Metabolism by Cytochrome P450scc Show Anti-Leukemia Effects, Having Low or Absent Calcemic Activity
Background Cytochrome P450scc metabolizes vitamin D3 to 20-hydroxyvitamin D3 (20(OH)D3) and 20,23(OH)2D3, as well as 1… Expand
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Highly Cited
2009
Highly Cited
2009
Sequential Metabolism of 7-Dehydrocholesterol to Steroidal 5,7-Dienes in Adrenal Glands and Its Biological Implication in the Skin
Since P450scc transforms 7-dehydrocholesterol (7DHC) to 7-dehydropregnenolone (7DHP) in vitro, we investigated sequential 7DHC… Expand
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Highly Cited
2004
Highly Cited
2004
A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin.
Following up on our previous findings that the skin possesses steroidogenic activity from progesterone, we now show widespread… Expand
Highly Cited
2003
Highly Cited
2003
A pathway for the metabolism of vitamin D3: Unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1)
Metabolites of vitamin D3 (D3) (cholecalciferol) are recognized as enzymatically formed chemicals in humans that can influence a… Expand
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