7-amino-4-carbamoylmethylcoumarin

Known as: ACC leaving group 
 
National Institutes of Health

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Coumarins

Papers overview

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2017
2017
Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity
Many biologically and chemically based approaches have been developed to design highly active and selective protease substrates… (More)
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2017
2017
Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families
Internally quenched fluorescent (IQF) peptide substrates originating from FRET (Förster Resonance Energy Transfer) are powerful… (More)
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2016
2016
Ubiquitin 7-amino-4-carbamoylmethylcoumarin as an improved fluorogenic substrate for deubiquitinating enzymes
 
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2010
2010
Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors.
Aminopeptidases process the N-terminal amino acids of target substrates by sequential cleavage of one residue at a time. They are… (More)
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2008
2008
Synthesis of folate-conjugated amphiphiles for tumor-targeted drug delivery.
Folic acid was derivatized specifically at its gamma-carboxyl group to retain its ligand-binding activity to the folate receptor… (More)
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2007
2007
Defining the extended substrate specificity of kallikrein 1-related peptidases.
Human kallikrein 1-related peptidases (KLKs) form a subfamily of 15 extracellular (chymo)tryptic-like serine proteases. KLKs 4, 5… (More)
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2006
2006
Determination of the substrate specificity of tripeptidyl-peptidase I using combinatorial peptide libraries and development of improved fluorogenic substrates.
Classical late-infantile neuronal ceroid lipofuscinosis is a fatal neurodegenerative disease caused by mutations in CLN2, the… (More)
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2003
2003
Facile synthesis of 7-amino-4-carbamoylmethylcoumarin (ACC)-containing solid supports and their corresponding fluorogenic protease substrates.
The bifunctional fluorophore, 7-amino-4-carbamoylmethylcoumarin (ACC) without any protection groups, was regioselectively… (More)
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2002
2002
Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore.
A highly efficient solid-phase synthesis method for the preparation of fluorogenic protease substrates based upon the… (More)
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Highly Cited
2000
Highly Cited
2000
Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries.
A method is presented for the preparation and use of fluorogenic peptide substrates that allows for the configuration of general… (More)
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