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7-amino-4-carbamoylmethylcoumarin
Known as:
ACC leaving group
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
Coumarins
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity
M. Poręba
,
G. Salvesen
,
M. Drąg
Nature Protocols
2017
Corpus ID: 23895951
Many biologically and chemically based approaches have been developed to design highly active and selective protease substrates…
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2017
2017
Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families
M. Poręba
,
A. Szalek
,
+10 authors
M. Drąg
Scientific reports
2017
Corpus ID: 1914338
Internally quenched fluorescent (IQF) peptide substrates originating from FRET (Förster Resonance Energy Transfer) are powerful…
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Highly Cited
2009
Highly Cited
2009
Aminopeptidase Fingerprints, an Integrated Approach for Identification of Good Substrates and Optimal Inhibitors*
M. Drąg
,
M. Bogyo
,
J. Ellman
,
G. Salvesen
The Journal of Biological Chemistry
2009
Corpus ID: 16096940
Aminopeptidases process the N-terminal amino acids of target substrates by sequential cleavage of one residue at a time. They are…
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2008
2008
Synthesis of folate-conjugated amphiphiles for tumor-targeted drug delivery.
S. Bhattacharya
,
A. Franz
,
Xiaoling Li
,
B. Jasti
Journal of drug targeting
2008
Corpus ID: 11654608
Folic acid was derivatized specifically at its gamma-carboxyl group to retain its ligand-binding activity to the folate receptor…
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Highly Cited
2007
Highly Cited
2007
Defining the extended substrate specificity of kallikrein 1-related peptidases
C. Borgoño
,
J. Gavigan
,
+4 authors
E. Diamandis
Biological chemistry
2007
Corpus ID: 8365909
Abstract Human kallikrein 1-related peptidases (KLKs) form a subfamily of 15 extracellular (chymo)tryptic-like serine proteases…
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2006
2006
Determination of the Substrate Specificity of Tripeptidyl-peptidase I Using Combinatorial Peptide Libraries and Development of Improved Fluorogenic Substrates*
Yu Tian
,
I. Sohar
,
John W. Taylor
,
P. Lobel
Journal of Biological Chemistry
2006
Corpus ID: 40154376
Classical late-infantile neuronal ceroid lipofuscinosis is a fatal neurodegenerative disease caused by mutations in CLN2, the…
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2003
2003
Facile synthesis of 7-amino-4-carbamoylmethylcoumarin (ACC)-containing solid supports and their corresponding fluorogenic protease substrates.
Qing Zhu
,
D. Li
,
M. Uttamchandani
,
S. Yao
Bioorganic & medicinal chemistry letters
2003
Corpus ID: 40448672
Highly Cited
2002
Highly Cited
2002
Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore.
Dustin J Maly
,
F. Leonetti
,
+4 authors
J. Ellman
The Journal of organic chemistry
2002
Corpus ID: 18732958
A highly efficient solid-phase synthesis method for the preparation of fluorogenic protease substrates based upon the…
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Highly Cited
2000
Highly Cited
2000
Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries.
J. Harris
,
B. J. Backes
,
F. Leonetti
,
S. Mahrus
,
J. Ellman
,
C. Craik
Proceedings of the National Academy of Sciences…
2000
Corpus ID: 25799560
A method is presented for the preparation and use of fluorogenic peptide substrates that allows for the configuration of general…
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