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7-amino-4-carbamoylmethylcoumarin

Known as: ACC leaving group 
 
National Institutes of Health

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1 relation

Broader (1)

Coumarins

Papers overview

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2017
2017
Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity
Many biologically and chemically based approaches have been developed to design highly active and selective protease substrates… Expand
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2017
2017
Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families
Internally quenched fluorescent (IQF) peptide substrates originating from FRET (Förster Resonance Energy Transfer) are powerful… Expand
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Highly Cited
2009
Highly Cited
2009
Aminopeptidase Fingerprints, an Integrated Approach for Identification of Good Substrates and Optimal Inhibitors*
Aminopeptidases process the N-terminal amino acids of target substrates by sequential cleavage of one residue at a time. They are… Expand
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2008
2008
Synthesis of folate-conjugated amphiphiles for tumor-targeted drug delivery.
Folic acid was derivatized specifically at its gamma-carboxyl group to retain its ligand-binding activity to the folate receptor… Expand
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2007
2007
Defining the extended substrate specificity of kallikrein 1-related peptidases
Abstract Human kallikrein 1-related peptidases (KLKs) form a subfamily of 15 extracellular (chymo)tryptic-like serine proteases… Expand
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2006
2006
Determination of the Substrate Specificity of Tripeptidyl-peptidase I Using Combinatorial Peptide Libraries and Development of Improved Fluorogenic Substrates*
Classical late-infantile neuronal ceroid lipofuscinosis is a fatal neurodegenerative disease caused by mutations in CLN2, the… Expand
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2003
2003
Facile synthesis of 7-amino-4-carbamoylmethylcoumarin (ACC)-containing solid supports and their corresponding fluorogenic protease substrates.
The bifunctional fluorophore, 7-amino-4-carbamoylmethylcoumarin (ACC) without any protection groups, was regioselectively… Expand
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Highly Cited
2002
Highly Cited
2002
Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore.
A highly efficient solid-phase synthesis method for the preparation of fluorogenic protease substrates based upon the… Expand
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Highly Cited
2000
Highly Cited
2000
Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries.
A method is presented for the preparation and use of fluorogenic peptide substrates that allows for the configuration of general… Expand
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