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7-amino-4-carbamoylmethylcoumarin

Known as: ACC leaving group 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Coumarins

Papers overview

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Highly Cited
2017
Highly Cited
2017
Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity
Many biologically and chemically based approaches have been developed to design highly active and selective protease substrates… 
2017
2017
Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families
Internally quenched fluorescent (IQF) peptide substrates originating from FRET (Förster Resonance Energy Transfer) are powerful… 
Highly Cited
2009
Highly Cited
2009
Aminopeptidase Fingerprints, an Integrated Approach for Identification of Good Substrates and Optimal Inhibitors*
Aminopeptidases process the N-terminal amino acids of target substrates by sequential cleavage of one residue at a time. They are… 
2008
2008
Synthesis of folate-conjugated amphiphiles for tumor-targeted drug delivery.
Folic acid was derivatized specifically at its gamma-carboxyl group to retain its ligand-binding activity to the folate receptor… 
Highly Cited
2007
Highly Cited
2007
Defining the extended substrate specificity of kallikrein 1-related peptidases
Abstract Human kallikrein 1-related peptidases (KLKs) form a subfamily of 15 extracellular (chymo)tryptic-like serine proteases… 
2006
2006
Determination of the Substrate Specificity of Tripeptidyl-peptidase I Using Combinatorial Peptide Libraries and Development of Improved Fluorogenic Substrates*
Classical late-infantile neuronal ceroid lipofuscinosis is a fatal neurodegenerative disease caused by mutations in CLN2, the… 
2003
2003
Facile synthesis of 7-amino-4-carbamoylmethylcoumarin (ACC)-containing solid supports and their corresponding fluorogenic protease substrates.
Highly Cited
2002
Highly Cited
2002
Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore.
A highly efficient solid-phase synthesis method for the preparation of fluorogenic protease substrates based upon the… 
Highly Cited
2000
Highly Cited
2000
Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries.
A method is presented for the preparation and use of fluorogenic peptide substrates that allows for the configuration of general… 
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