7,8-dihydroneopterin

Measurement of plasma neopterin by HPLC with fluorescence detection is used clinically as a marker of immune cell activation in… Expand

The atherosclerotic plaque is an inflammatory site where macrophage cells are exposed to cytotoxic oxidised low density… Expand

Low density lipoprotein (LDL) oxidation within the artery wall likely represents a key event in the formation of atherosclerotic… Expand

Interferon-gamma stimulation of human macrophages causes the synthesis and release of neopterin and its reduced form 7,8… Expand

Neopterin and the reduced form, 7,8-dihydroneopterin (78NP) are pteridines released from macrophages when stimulated with gamma… Expand

In vitro, interferon-gamma stimulates primate monocytes/macrophages to produce the pteridines neopterin and 7,8-dihydroneopterin… Expand

Neopterin and 7,8-dihydroneopterin, two compounds which are secreted by activated macrophages, have been shown to interfere with… Expand

Previously, it has been shown that pteridine derivatives are capable of modulating the action of free radicals and both… Expand

The neopterin derivatives, neopterin and 7,8-dihydroneopterin, modulate the cellular oxidant-antioxidant balance as well as the… Expand

Tumor necrosis factor-alpha and the formation of reactive oxygen intermediates are central mediators of apoptosis. Recent data… Expand