Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

68Ga-DOTA-exendin-4

Known as: Gallium Ga 68-DOTA-exendin-4, [Lys40(Ahx-DOTA-68Ga)NH2]-exendin-4 
A radiopharmaceutical composed of the glucagon-like peptide 1 receptor (GLP-1R) agonist exendin-4 linked by the macrocyclic chelator 1,4,7,10… Expand
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Organometallic CompoundsPeptides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Central Nervous System Regulation of Intestinal Lipoprotein Metabolism by Glucagon-Like Peptide-1 via a Brain-Gut Axis.
OBJECTIVE Intestinal overproduction of atherogenic chylomicron particles postprandially is an important component of diabetic… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
Is this relevant?
2014
2014
64Cu- and 68Ga-labelled [Nle(14),Lys(40)(Ahx-NODAGA)NH2]-exendin-4 for pancreatic beta cell imaging in rats.
PURPOSE Glucagon-like peptide-1 receptor (GLP-1R) is a molecular target for imaging of pancreatic beta cells. We compared the… Expand
Is this relevant?
2013
2013
Oral delivery of bioencapsulated exendin-4 expressed in chloroplasts lowers blood glucose level in mice and stimulates insulin secretion in beta-TC6 cells.
Glucagon-like peptide (GLP-1) increases insulin secretion but is rapidly degraded (half-life: 2 min in circulation). GLP-1… Expand
Is this relevant?
Highly Cited
2012
Highly Cited
2012
Glucagon-like peptide-1 receptor imaging with [Lys40(Ahx-HYNIC-99mTc/EDDA)NH2]-exendin-4 for the detection of insulinoma
PurposeThe objective of this article is to present a new method for the diagnosis of insulinoma with the use of [Lys40(Ahx-HYNIC… Expand
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • table 2
Is this relevant?
Highly Cited
2011
Highly Cited
2011
The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test.
We have earlier shown that the glucagon-like peptide 1 receptor agonist exendin-4 stimulates neurogenesis in the subventricular… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Exendin-4–Based Radiopharmaceuticals for Glucagonlike Peptide-1 Receptor PET/CT and SPECT/CT
Strong overexpression of glucagonlike peptide-1 (GLP-1) receptors in human insulinoma provides an attractive target for imaging… Expand
  • table 1
  • table 2
  • table 3
  • table 4
  • table 5
Is this relevant?
2010
2010
The fatty acid conjugated exendin-4 analogs for type 2 antidiabetic therapeutics.
Improved glucagon-like peptide-1 (GLP-1) receptor activation is considered one of the most effective targets for antidiabetic… Expand
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
2010
2010
Biochemical, pharmaceutical and therapeutic properties of long-acting lithocholic acid derivatized exendin-4 analogs.
Alterations in the physicochemical characteristics of peptide drugs can transform their biological and pharmaceutical features… Expand
Is this relevant?
2009
2009
A new orally available glucagon-like peptide-1 receptor agonist, biotinylated exendin-4, displays improved hypoglycemic effects in db/db mice.
An orally active glucagon-like peptide-1 (GLP-1) formulation would have great advantages over conventional injectable therapies… Expand
  • figure 2
  • figure 3
  • table 1
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2006
Highly Cited
2006
[Lys40(Ahx-DTPA-111In)NH2]exendin-4, a very promising ligand for glucagon-like peptide-1 (GLP-1) receptor targeting.
UNLABELLED High levels of glucagon-like peptide-1 (GLP-1) receptor expression in human insulinomas and gastrinomas provide an… Expand
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE