FAQ

68Ga-DOTA-exendin-4

Known as: Gallium Ga 68-DOTA-exendin-4, [Lys40(Ahx-DOTA-68Ga)NH2]-exendin-4 
A radiopharmaceutical composed of the glucagon-like peptide 1 receptor (GLP-1R) agonist exendin-4 linked by the macrocyclic chelator 1,4,7,10… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2016
012319942016

Related topics

Related topics

2 relations

Broader (2)

Organometallic CompoundsPeptides

Related mentions per year

Related mentions per year

1940-2018
19401960198020002020
68Ga-DOTA-exendin-4
Peptides
Organometallic Compounds

Papers overview

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2015
2015
Parabrachial Nucleus Contributions to Glucagon-Like Peptide-1 Receptor Agonist-Induced Hypophagia
Exendin-4 (Ex4), a glucagon-like peptide-1 receptor (GLP-1R) agonist approved to treat type 2 diabetes mellitus, is well known to… (More)
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2014
2014
Exendin-4 ameliorates cardiac ischemia/reperfusion injury via caveolae and caveolins-3
BACKGROUND Exendin-4, an exogenous glucagon-like peptide-1 receptor (GLP-1R) agonist, protects the heart from ischemia… (More)
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2014
2014
Anti-inflammatory effect of exendin-4 postconditioning during myocardial ischemia and reperfusion
High mobility group box 1 protein (HMGB1) plays an important role in myocardial ischemia and reperfusion (I/R) injury… (More)
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2013
2013
In vivo imaging of the glucagonlike peptide 1 receptor in the pancreas with 68Ga-labeled DO3A-exendin-4.
UNLABELLED The glucagonlike peptide 1 receptor (GLP-1R) is mainly expressed on β-cells in the islets of Langerhans and is… (More)
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2013
2013
Oral delivery of an anti-diabetic peptide drug via conjugation and complexation with low molecular weight chitosan.
Despite the therapeutic potential of exendin-4 as a glucagon-like peptide-1 (GLP-1) mimetic for the treatment of type 2 diabetes… (More)
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2013
2013
18F-radiolabeled GLP-1 analog exendin-4 for PET/CT imaging of insulinoma in small animals.
BACKGROUND Insulinoma is a neuroendocrine tumor derived from the β cells of pancreatic islets. They are usually relatively… (More)
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2012
2012
Glucagon-like peptide-1 receptor overexpression in cancer and its impact on clinical applications
Peptide hormones of the glucagon-like peptide (GLP) family play an increasing clinical role, such as GLP-1 in diabetes therapy… (More)
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2009
2009
A new orally available glucagon-like peptide-1 receptor agonist, biotinylated exendin-4, displays improved hypoglycemic effects in db/db mice.
An orally active glucagon-like peptide-1 (GLP-1) formulation would have great advantages over conventional injectable therapies… (More)
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Highly Cited
1995
Highly Cited
1995
Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites.
The distribution and biochemical properties of glucagon-like peptide (GLP)-1(7-36) amide (GLP-1) binding sites in the rat brain… (More)
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1994
1994
Use of 125I-[Y39]exendin-4 to characterize exendin receptors on dispersed pancreatic acini and gastric chief cells from guinea pig.
We synthesized and iodinated an exendin-4 analogue, [Y39]exendin-4 (700 Ci/mmol), for use as a radioligand to characterize… (More)
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