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68Ga-DOTA-exendin-4
Known as:
Gallium Ga 68-DOTA-exendin-4
, [Lys40(Ahx-DOTA-68Ga)NH2]-exendin-4
A radiopharmaceutical composed of the glucagon-like peptide 1 receptor (GLP-1R) agonist exendin-4 linked by the macrocyclic chelator 1,4,7,10…
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National Institutes of Health
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Related topics
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2 relations
Broader (2)
Organometallic Compounds
Peptides
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Central Nervous System Regulation of Intestinal Lipoprotein Metabolism by Glucagon-Like Peptide-1 via a Brain–Gut Axis
Sarah Farr
,
Christopher Baker
,
+4 authors
K. Adeli
Arteriosclerosis, thrombosis, and vascular…
2015
Corpus ID: 38362928
Objective— Intestinal overproduction of atherogenic chylomicron particles postprandially is an important component of diabetic…
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Highly Cited
2014
Highly Cited
2014
64Cu- and 68Ga-labelled [Nle(14),Lys(40)(Ahx-NODAGA)NH2]-exendin-4 for pancreatic beta cell imaging in rats.
K. Mikkola
,
C. Yim
,
+15 authors
P. Nuutila
Molecular imaging and biology : MIB : the…
2014
Corpus ID: 195683144
PURPOSE Glucagon-like peptide-1 receptor (GLP-1R) is a molecular target for imaging of pancreatic beta cells. We compared the…
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Highly Cited
2013
Highly Cited
2013
Oral delivery of bioencapsulated exendin-4 expressed in chloroplasts lowers blood glucose level in mice and stimulates insulin secretion in beta-TC6 cells.
Kwang-Chul Kwon
,
Ramya Nityanandam
,
J. New
,
H. Daniell
Plant biotechnology journal
2013
Corpus ID: 38766074
Glucagon-like peptide (GLP-1) increases insulin secretion but is rapidly degraded (half-life: 2 min in circulation). GLP-1…
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Highly Cited
2012
Highly Cited
2012
Glucagon-like peptide-1 receptor imaging with [Lys40(Ahx-HYNIC-99mTc/EDDA)NH2]-exendin-4 for the detection of insulinoma
A. Sowa-Staszczak
,
D. Pach
,
+13 authors
A. Hubalewska-Dydejczyk
European Journal of Nuclear Medicine and…
2012
Corpus ID: 18384259
PurposeThe objective of this article is to present a new method for the diagnosis of insulinoma with the use of [Lys40(Ahx-HYNIC…
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Highly Cited
2011
Highly Cited
2011
The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test.
R. Isacson
,
Elisabet Nielsen
,
+4 authors
L. Wikström
European journal of pharmacology
2011
Corpus ID: 5211774
Highly Cited
2010
Highly Cited
2010
Exendin-4–Based Radiopharmaceuticals for Glucagonlike Peptide-1 Receptor PET/CT and SPECT/CT
D. Wild
,
A. Wicki
,
+6 authors
H. Mäcke
Journal of Nuclear Medicine
2010
Corpus ID: 25029377
Strong overexpression of glucagonlike peptide-1 (GLP-1) receptors in human insulinoma provides an attractive target for imaging…
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Highly Cited
2010
Highly Cited
2010
The fatty acid conjugated exendin-4 analogs for type 2 antidiabetic therapeutics.
S. Chae
,
Y. Choi
,
Sohee Son
,
S. Jung
,
D. S. Lee
,
Kang-Choon Lee
Journal of controlled release : official journal…
2010
Corpus ID: 8741850
Highly Cited
2009
Highly Cited
2009
A new orally available glucagon-like peptide-1 receptor agonist, biotinylated exendin-4, displays improved hypoglycemic effects in db/db mice.
Cheng-Hao Jin
,
S. Chae
,
+5 authors
Kang-Choon Lee
Journal of controlled release : official journal…
2009
Corpus ID: 25133663
Highly Cited
2007
Highly Cited
2007
[Lys40(Ahx-DTPA-111In)NH2]-Exendin-4 Is a Highly Efficient Radiotherapeutic for Glucagon-Like Peptide-1 Receptor–Targeted Therapy for Insulinoma
A. Wicki
,
D. Wild
,
+8 authors
G. Christofori
Clinical Cancer Research
2007
Corpus ID: 8992164
Purpose: Although metabolic changes make diagnosis of insulinoma relatively easy, surgical removal is hampered by difficulties in…
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Highly Cited
2006
Highly Cited
2006
[Lys40(Ahx-DTPA-111In)NH2]exendin-4, a very promising ligand for glucagon-like peptide-1 (GLP-1) receptor targeting.
D. Wild
,
M. Béhé
,
+7 authors
H. Mäcke
Journal of nuclear medicine : official…
2006
Corpus ID: 13639527
UNLABELLED High levels of glucagon-like peptide-1 (GLP-1) receptor expression in human insulinomas and gastrinomas provide an…
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