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68Ga-DOTA-exendin-4

Known as: Gallium Ga 68-DOTA-exendin-4, [Lys40(Ahx-DOTA-68Ga)NH2]-exendin-4 
A radiopharmaceutical composed of the glucagon-like peptide 1 receptor (GLP-1R) agonist exendin-4 linked by the macrocyclic chelator 1,4,7,10… Expand
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Organometallic CompoundsPeptides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Central Nervous System Regulation of Intestinal Lipoprotein Metabolism by Glucagon-Like Peptide-1 via a Brain–Gut Axis
Objective— Intestinal overproduction of atherogenic chylomicron particles postprandially is an important component of diabetic… Expand
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Highly Cited
2014
Highly Cited
2014
64Cu- and 68Ga-labelled [Nle(14),Lys(40)(Ahx-NODAGA)NH2]-exendin-4 for pancreatic beta cell imaging in rats.
PURPOSE Glucagon-like peptide-1 receptor (GLP-1R) is a molecular target for imaging of pancreatic beta cells. We compared the… Expand
Highly Cited
2013
Highly Cited
2013
Oral delivery of bioencapsulated exendin-4 expressed in chloroplasts lowers blood glucose level in mice and stimulates insulin secretion in beta-TC6 cells.
Glucagon-like peptide (GLP-1) increases insulin secretion but is rapidly degraded (half-life: 2 min in circulation). GLP-1… Expand
Highly Cited
2012
Highly Cited
2012
Glucagon-like peptide-1 receptor imaging with [Lys40(Ahx-HYNIC-99mTc/EDDA)NH2]-exendin-4 for the detection of insulinoma
PurposeThe objective of this article is to present a new method for the diagnosis of insulinoma with the use of [Lys40(Ahx-HYNIC… Expand
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Highly Cited
2011
Highly Cited
2011
The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test.
We have earlier shown that the glucagon-like peptide 1 receptor agonist exendin-4 stimulates neurogenesis in the subventricular… Expand
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Highly Cited
2010
Highly Cited
2010
Exendin-4–Based Radiopharmaceuticals for Glucagonlike Peptide-1 Receptor PET/CT and SPECT/CT
Strong overexpression of glucagonlike peptide-1 (GLP-1) receptors in human insulinoma provides an attractive target for imaging… Expand
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Highly Cited
2010
Highly Cited
2010
The fatty acid conjugated exendin-4 analogs for type 2 antidiabetic therapeutics.
Improved glucagon-like peptide-1 (GLP-1) receptor activation is considered one of the most effective targets for antidiabetic… Expand
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Highly Cited
2009
Highly Cited
2009
A new orally available glucagon-like peptide-1 receptor agonist, biotinylated exendin-4, displays improved hypoglycemic effects in db/db mice.
An orally active glucagon-like peptide-1 (GLP-1) formulation would have great advantages over conventional injectable therapies… Expand
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Highly Cited
2007
Highly Cited
2007
[Lys40(Ahx-DTPA-111In)NH2]-Exendin-4 Is a Highly Efficient Radiotherapeutic for Glucagon-Like Peptide-1 Receptor–Targeted Therapy for Insulinoma
Purpose: Although metabolic changes make diagnosis of insulinoma relatively easy, surgical removal is hampered by difficulties in… Expand
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Highly Cited
2006
Highly Cited
2006
[Lys40(Ahx-DTPA-111In)NH2]exendin-4, a very promising ligand for glucagon-like peptide-1 (GLP-1) receptor targeting.
UNLABELLED High levels of glucagon-like peptide-1 (GLP-1) receptor expression in human insulinomas and gastrinomas provide an… Expand
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