6-methylthiopurine

Known as: 6-methylmercaptopurine, methylmercaptopurine 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1959-2017
05101519592017

Papers overview

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Highly Cited
2010
Highly Cited
2010
BACKGROUND Thiopurines have proven efficacy in long-term maintenance therapy of inflammatory bowel disease (IBD). Limited data… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND & AIMS Many IBD patients not responding to azathioprine (AZA) or 6-mercaptopurine (6-MP) preferentially metabolize 6… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Many non-responders to azathioprine or mercaptopurine (6-mercaptopurine) have high normal thiopurine methyltransferase… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND & AIMS Approximately 40% of inflammatory bowel disease (IBD) patients fail to benefit from 6-mercaptopurine (6-MP… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND & AIMS The effects of 6-mercaptopurine (6-MP) are mediated via its intracellular conversion to 6-thioguanine (6-TG… (More)
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1999
1999
Angiogenesis has been identified as an important target for antineoplastic therapy. The use of purine analogue antimetabolites in… (More)
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1995
1995
As part of a programme assessing the pharmacokinetics of oral thiopurines given for lymphoblastic leukaemia, we assayed… (More)
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1992
1992
A reversed-phase high-performance liquid chromatographic assay was developed to quantify intracellular metabolites of the… (More)
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1992
1992
The immunosuppressive efficacy of azathioprine is related to its rapid metabolism in vivo to 6-mercaptopurine (6MP), with… (More)
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1983
1983
Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurines and thiopyrimidines. Human kidney TPMT was… (More)
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