Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

6'-guanidinonaltrindole

Known as: 6'-GNTI 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

GuanidinesNaltrexone
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Allosterism within δ Opioid–κ Opioid Receptor Heteromers in Peripheral Sensory Neurons: Regulation of κ Opioid Agonist Efficacy
There is abundant evidence for formation of G protein-coupled receptor heteromers in heterologous expression systems, but little… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
2016
2016
Molecular switches of the κ opioid receptor triggered by 6′-GNTI and 5′-GNTI
The κ opioid receptor (κOR) is a member of G-protein-coupled receptors, and is considered as a promising drug target for treating… Expand
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
2016
2016
The G‐protein biased partial κ opioid receptor agonist 6′‐GNTI blocks hippocampal paroxysmal discharges without inducing aversion
With a prevalence of 1–2%, epilepsies belong to the most frequent neurological diseases worldwide. Although antiepileptic drugs… Expand
2015
2015
Noribogaine is a G-protein biased κ-opioid receptor agonist
Noribogaine is the long-lived human metabolite of the anti-addictive substance ibogaine. Noribogaine efficaciously reaches the… Expand
  • figure 1
  • table 1
  • figure 2
  • table 2
  • table 3
Highly Cited
2013
Highly Cited
2013
Functional Selectivity of 6′-Guanidinonaltrindole (6′-GNTI) at κ-Opioid Receptors in Striatal Neurons*
Background: 6′-Guanidinonaltrindole (6′-GNTI) activates G protein coupling to κ-opioid receptors (KOR) without β-arrestin2… Expand
  • figure 1
  • table 2
  • table 1
  • figure 2
  • figure 3
Highly Cited
2012
Highly Cited
2012
6′-Guanidinonaltrindole (6′-GNTI) Is a G Protein-biased κ-Opioid Receptor Agonist That Inhibits Arrestin Recruitment*
Background: Arrestin recruitment to the κ-opioid receptor (KOR) has been linked to several adverse effects of analgesics, such as… Expand
  • figure 1
  • figure 2
2012
2012
Allosteric Interactions between δ and κ Opioid Receptors in Peripheral Sensory Neurons
The peripheral δ opioid receptor (DOR) is an attractive target for analgesic drug development. There is evidence that DOR can… Expand
  • figure 1
  • figure 3
  • figure 2
  • figure 4
  • figure 5
2010
2010
Study of a structurally similar kappa opioid receptor agonist and antagonist pair by molecular dynamics simulations
AbstractAmong the structurally similar guanidinonaltrindole (GNTI) compounds, 5′-GNTI is an antagonist while 6′-GNTI is an… Expand
Highly Cited
2005
Highly Cited
2005
A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers.
There has been much speculation regarding the functional relevance of G protein-coupled receptor heterodimers, primarily because… Expand
  • figure 1
  • table 1
  • table 2
  • figure 2
  • figure 3
Highly Cited
2005
Highly Cited
2005
Diversifying the repertoire of G protein-coupled receptors through oligomerization.
Oligomerization of G protein-coupled receptors (GPCRs) has received much attention over the past several years (1, 2). The… Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE