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6'-guanidinonaltrindole

Known as: 6'-GNTI 
 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

GuanidinesNaltrexone
analogs & derivatives

Papers overview

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2018
2018
Allosterism within δ Opioid–κ Opioid Receptor Heteromers in Peripheral Sensory Neurons: Regulation of κ Opioid Agonist Efficacy
There is abundant evidence for formation of G protein-coupled receptor heteromers in heterologous expression systems, but little… Expand
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2016
2016
Molecular switches of the κ opioid receptor triggered by 6′-GNTI and 5′-GNTI
The κ opioid receptor (κOR) is a member of G-protein-coupled receptors, and is considered as a promising drug target for treating… Expand
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2016
2016
The G‐protein biased partial κ opioid receptor agonist 6′‐GNTI blocks hippocampal paroxysmal discharges without inducing aversion
With a prevalence of 1–2%, epilepsies belong to the most frequent neurological diseases worldwide. Although antiepileptic drugs… Expand
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2015
2015
Noribogaine is a G-protein biased κ-opioid receptor agonist
Noribogaine is the long-lived human metabolite of the anti-addictive substance ibogaine. Noribogaine efficaciously reaches the… Expand
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Highly Cited
2013
Highly Cited
2013
Functional Selectivity of 6′-Guanidinonaltrindole (6′-GNTI) at κ-Opioid Receptors in Striatal Neurons*
Background: 6′-Guanidinonaltrindole (6′-GNTI) activates G protein coupling to κ-opioid receptors (KOR) without β-arrestin2… Expand
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Highly Cited
2012
Highly Cited
2012
6′-Guanidinonaltrindole (6′-GNTI) Is a G Protein-biased κ-Opioid Receptor Agonist That Inhibits Arrestin Recruitment*
Background: Arrestin recruitment to the κ-opioid receptor (KOR) has been linked to several adverse effects of analgesics, such as… Expand
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2012
2012
Allosteric Interactions between δ and κ Opioid Receptors in Peripheral Sensory Neurons
The peripheral δ opioid receptor (DOR) is an attractive target for analgesic drug development. There is evidence that DOR can… Expand
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2010
2010
Study of a structurally similar kappa opioid receptor agonist and antagonist pair by molecular dynamics simulations
AbstractAmong the structurally similar guanidinonaltrindole (GNTI) compounds, 5′-GNTI is an antagonist while 6′-GNTI is an… Expand
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Highly Cited
2005
Highly Cited
2005
A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers.
There has been much speculation regarding the functional relevance of G protein-coupled receptor heterodimers, primarily because… Expand
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Highly Cited
2005
Highly Cited
2005
Diversifying the repertoire of G protein-coupled receptors through oligomerization.
Oligomerization of G protein-coupled receptors (GPCRs) has received much attention over the past several years (1, 2). The… Expand
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