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6'-guanidinonaltrindole
Known as:
6'-GNTI
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (2)
Guanidines
Naltrexone
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Signaling characteristics and functional regulation of delta opioid-kappa opioid receptor (DOP-KOP) heteromers in peripheral sensory neurons
B. Jacobs
,
Miryam M. Pando
,
+5 authors
K. Berg
Neuropharmacology
2019
Corpus ID: 72335006
2016
2016
The G‐protein biased partial κ opioid receptor agonist 6′‐GNTI blocks hippocampal paroxysmal discharges without inducing aversion
L. Zangrandi
,
J. Burtscher
,
James P. Mackay
,
W. Colmers
,
C. Schwarzer
British Journal of Pharmacology
2016
Corpus ID: 29108717
With a prevalence of 1–2%, epilepsies belong to the most frequent neurological diseases worldwide. Although antiepileptic drugs…
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2016
2016
Molecular switches of the κ opioid receptor triggered by 6′-GNTI and 5′-GNTI
Jian-xin Cheng
,
Xianqiang Sun
,
Weihua Li
,
Guixia Liu
,
Yaoquan Tu
,
Yun Tang
Scientific Reports
2016
Corpus ID: 18977778
The κ opioid receptor (κOR) is a member of G-protein-coupled receptors, and is considered as a promising drug target for treating…
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2015
2015
Noribogaine is a G-protein biased κ-opioid receptor agonist
Emeline L. Maillet
,
N. Milon
,
+4 authors
D. Mash
Neuropharmacology
2015
Corpus ID: 31635090
Highly Cited
2013
Highly Cited
2013
Functional Selectivity of 6′-Guanidinonaltrindole (6′-GNTI) at κ-Opioid Receptors in Striatal Neurons*
Cullen L. Schmid
,
J. Streicher
,
C. Groer
,
Thomas A. Munro
,
Lei Zhou
,
L. Bohn
Journal of Biological Chemistry
2013
Corpus ID: 25814114
Background: 6′-Guanidinonaltrindole (6′-GNTI) activates G protein coupling to κ-opioid receptors (KOR) without β-arrestin2…
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Highly Cited
2012
Highly Cited
2012
6′-Guanidinonaltrindole (6′-GNTI) Is a G Protein-biased κ-Opioid Receptor Agonist That Inhibits Arrestin Recruitment*
M. Rives
,
Mary Rossillo
,
L. Liu-Chen
,
J. Javitch
Journal of Biological Chemistry
2012
Corpus ID: 24370434
Background: Arrestin recruitment to the κ-opioid receptor (KOR) has been linked to several adverse effects of analgesics, such as…
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Highly Cited
2012
Highly Cited
2012
Allosteric Interactions between δ and κ Opioid Receptors in Peripheral Sensory Neurons
K. Berg
,
Matthew P. Rowan
,
+8 authors
W. Clarke
Molecular Pharmacology
2012
Corpus ID: 11897277
The peripheral δ opioid receptor (DOR) is an attractive target for analgesic drug development. There is evidence that DOR can…
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2010
2010
Study of a structurally similar kappa opioid receptor agonist and antagonist pair by molecular dynamics simulations
M. Koliński
,
S. Filipek
Journal of Molecular Modeling
2010
Corpus ID: 36713452
AbstractAmong the structurally similar guanidinonaltrindole (GNTI) compounds, 5′-GNTI is an antagonist while 6′-GNTI is an…
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Highly Cited
2005
Highly Cited
2005
A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers.
M. Waldhoer
,
Jamie Fong
,
+5 authors
J. Whistler
Proceedings of the National Academy of Sciences…
2005
Corpus ID: 30193303
There has been much speculation regarding the functional relevance of G protein-coupled receptor heterodimers, primarily because…
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Highly Cited
2005
Highly Cited
2005
Diversifying the repertoire of G protein-coupled receptors through oligomerization.
P. Park
,
K. Palczewski
Proceedings of the National Academy of Sciences…
2005
Corpus ID: 19721071
Oligomerization of G protein-coupled receptors (GPCRs) has received much attention over the past several years (1, 2). The…
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