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There is abundant evidence for formation of G protein-coupled receptor heteromers in heterologous expression systems, but little… Expand The κ opioid receptor (κOR) is a member of G-protein-coupled receptors, and is considered as a promising drug target for treating… Expand With a prevalence of 1–2%, epilepsies belong to the most frequent neurological diseases worldwide. Although antiepileptic drugs… Expand Noribogaine is the long-lived human metabolite of the anti-addictive substance ibogaine. Noribogaine efficaciously reaches the… Expand Background: 6′-Guanidinonaltrindole (6′-GNTI) activates G protein coupling to κ-opioid receptors (KOR) without β-arrestin2… Expand Background: Arrestin recruitment to the κ-opioid receptor (KOR) has been linked to several adverse effects of analgesics, such as… Expand The peripheral δ opioid receptor (DOR) is an attractive target for analgesic drug development. There is evidence that DOR can… Expand AbstractAmong the structurally similar guanidinonaltrindole (GNTI) compounds, 5′-GNTI is an antagonist while 6′-GNTI is an… Expand There has been much speculation regarding the functional relevance of G protein-coupled receptor heterodimers, primarily because… Expand Oligomerization of G protein-coupled receptors (GPCRs) has received much attention over the past several years (1, 2). The… Expand