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6'-guanidinonaltrindole

Known as: 6'-GNTI 
 
National Institutes of Health

Papers overview

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2018
2018
There is abundant evidence for formation of G protein-coupled receptor heteromers in heterologous expression systems, but little… Expand
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2016
2016
The κ opioid receptor (κOR) is a member of G-protein-coupled receptors, and is considered as a promising drug target for treating… Expand
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2016
2016
With a prevalence of 1–2%, epilepsies belong to the most frequent neurological diseases worldwide. Although antiepileptic drugs… Expand
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2015
2015
Noribogaine is the long-lived human metabolite of the anti-addictive substance ibogaine. Noribogaine efficaciously reaches the… Expand
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Highly Cited
2013
Highly Cited
2013
Background: 6′-Guanidinonaltrindole (6′-GNTI) activates G protein coupling to κ-opioid receptors (KOR) without β-arrestin2… Expand
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Highly Cited
2012
Highly Cited
2012
Background: Arrestin recruitment to the κ-opioid receptor (KOR) has been linked to several adverse effects of analgesics, such as… Expand
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2012
2012
The peripheral δ opioid receptor (DOR) is an attractive target for analgesic drug development. There is evidence that DOR can… Expand
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2010
2010
AbstractAmong the structurally similar guanidinonaltrindole (GNTI) compounds, 5′-GNTI is an antagonist while 6′-GNTI is an… Expand
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Highly Cited
2005
Highly Cited
2005
There has been much speculation regarding the functional relevance of G protein-coupled receptor heterodimers, primarily because… Expand
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Highly Cited
2005
Highly Cited
2005
Oligomerization of G protein-coupled receptors (GPCRs) has received much attention over the past several years (1, 2). The… Expand
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