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5-oxoprolinase (ATP-hydrolysing) activity

Known as: 5-oxo-L-prolinase activity, 5-oxo-L-proline amidohydrolase (ATP-hydrolysing), oxoprolinase activity 
Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H(2)O = L-glutamate + ADP + 2 H(+) + phosphate. [EC:3.5.2.9, RHEA:10351]
National Institutes of Health

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Related topics

1 relation
OPLAH gene

Papers overview

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Highly Cited
1988
Highly Cited
1988
Tissue-specific regulation of pyroglutamate aminopeptidase II activity by thyroid hormones.
Among the enzymes capable of degrading thyrotropin-releasing hormone (TRH) in vitro, two pyroglutamate aminopeptidases (PGA) are… 
1982
1982
New substrates of 5-oxo-L-prolinase.
1982
1982
Effect of sulfhydryl group modification on the activities of 5-oxo-L-prolinase.
Highly Cited
1981
Highly Cited
1981
Stimulation of hepatic glutathione formation by administration of L-2-oxothiazolidine-4-carboxylate, a 5-oxo-L-prolinase substrate.
5-Oxo-L-prolinase, the enzyme that catalyzes the conversion of 5-oxo-L-proline to L-glutamate coupled to the cleavage of ATP to… 
Highly Cited
1979
Highly Cited
1979
Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond.
The enzymatic hydrolysis of thyroliberin (< Glu-His-Pro-NH2) by serum enzymes can be preferentially inhibited by 1 mM… 
1979
1979
Purification and properties of brain cathepsin B. Evidence for cleavage of pituitary lipotropins.
1 CM-cellulose chromatography of calf brain extracts revealed the presence of several enzymes hydrolysing benzoyiarginyl… 
1975
1975
5-Oxo-L-prolinase (L-pyroglutamate hydrolase). Purification and catalytic properties.
Highly Cited
1975
Highly Cited
1975
Human skin proteases: separation and characterization of two alkaline proteases, one splitting trypsin and the other chymotrypsin substrates.
: Two alkaline proteases, one splitting preferentially the substrates of chymotrypsin (ATEE) and the other one those of trypsin… 
Highly Cited
1974
Highly Cited
1974
PYROGLUTAMIC ACIDURIA Studies in an Infant with Chronic Metabolic Acidosis
A one‐year‐old girl with chronic metabolic acidosis was found to have normal renal acidi‐fication. In the urine, however, she… 
Highly Cited
1964
Highly Cited
1964
Properties of the Penicillin Deacylase Enzyme of Escherichia coli
THE microbial enzyme which hydrolyses the side-chain from a penicillin to give 6-aminopenicillanic acid (6-APA) and carboxylic… 
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