5-hydroxymethyluracil

Known as: 5-(hydroxymethyl)-2,4(1H,3H)-pyrimidinedione, hydroxymethyluracil 
 
National Institutes of Health

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Highly Cited
2014
Highly Cited
2014
Ten eleven translocation (Tet) enzymes oxidize the epigenetically important DNA base 5-methylcytosine (mC) stepwise to 5… (More)
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2012
2012
The mammalian DNA glycosylase--methyl-CpG binding domain protein 4 (MBD4)--is involved in active DNA demethylation via the base… (More)
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Highly Cited
2012
Highly Cited
2012
The mammalian thymine DNA glycosylase (TDG) is implicated in active DNA demethylation via the base excision repair pathway. TDG… (More)
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Highly Cited
2012
Highly Cited
2012
Some Ts in nuclear DNA of trypanosomes and Leishmania are hydroxylated and glucosylated to yield base J (β-D-glucosyl… (More)
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Highly Cited
2011
Highly Cited
2011
DNA methylation is a major epigenetic mechanism for gene silencing. Whereas methyltransferases mediate cytosine methylation, it… (More)
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Highly Cited
2010
Highly Cited
2010
5-Hydroxymethylcytosine (hmC) was recently detected as the sixth base in mammalian tissue at so far controversial levels. The… (More)
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2000
2000
The oxidation of thymine in DNA can generate a base pair between 5-hydroxymethyluracil (HmU) and adenine, whereas the oxidation… (More)
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1996
1996
The thymine oxidative lesion-5-hydroxymethyluracil (HMUra)-was measured in urine collected from cancer patients. These patients… (More)
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Highly Cited
1995
Highly Cited
1995
Inflammatory cells such as phagocytes, neutrophils, and macrophages have been implicated in the pathogenesis of several forms of… (More)
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Highly Cited
1972
Highly Cited
1972
A method is given for small-scale preparation of DNA from 1.0-1.5g of adult rat tissues. The product from brain or liver is… (More)
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