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5-fluoroorotic acid

Known as: fluoroorotic acid, orotic acid, 5-fluoro- 
 
National Institutes of Health

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Highly Cited
2004
Highly Cited
2004
SummaryA system is described for gene disruption and replacement in Schizosaccharomyces pombe based on the homologous selectable… Expand
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Highly Cited
2003
Highly Cited
2003
In contrast to the high accumulation in sequence data for hyperthermophilic archaea, methodology for genetically manipulating… Expand
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Highly Cited
2001
Highly Cited
2001
The DAN/TIR genes of Saccharomyces cerevisiae encode homologous mannoproteins, some of which are essential for anaerobic growth… Expand
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Highly Cited
2001
Highly Cited
2001
Rsp5p, ubiquitin-protein ligase, an enzyme of the ubiquitination pathway, contains three WW domains that mediate protein-protein… Expand
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Highly Cited
1999
Highly Cited
1999
The Schizosaccharomyces pombe checkpoint gene named rad3(+) encodes an ATM-homologous protein kinase that shares a highly… Expand
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Highly Cited
1995
Highly Cited
1995
BACKGROUND DNA replication and mitosis are triggered by activation of kinase complexes, each made up of a cyclin and a cyclin… Expand
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Highly Cited
1993
Highly Cited
1993
Genetic manipulation of Candida albicans is constrained by its diploid genome and asexual life cycle. Recessive mutations are not… Expand
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Highly Cited
1992
Highly Cited
1992
Spontaneous mutants requiring uracil were isolated from both varieties of Cryptococcus neoformans by plating on 5-fluoroorotic… Expand
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Highly Cited
1989
Highly Cited
1989
Unlike mammalian cells, malarial parasites are completely dependent on de novo pyrimidine metabolism. Even though these parasites… Expand
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Highly Cited
1987
Highly Cited
1987
5-FOA is an extremely useful reagent for the selection of Ura- cells amid a population of Ura+ cells. The selection is effective… Expand
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