5-fluoroorotic acid

Known as: fluoroorotic acid, orotic acid, 5-fluoro- 
 
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
We report development of a genetic system for making targeted gene knockouts in Clostridium thermocellum, a thermophilic… (More)
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Highly Cited
2003
Highly Cited
2003
In contrast to the high accumulation in sequence data for hyperthermophilic archaea, methodology for genetically manipulating… (More)
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Highly Cited
2000
Highly Cited
2000
To facilitate the functional genomic analysis of an archaeon, we have developed a homologous gene replacement strategy for… (More)
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Highly Cited
1993
Highly Cited
1993
Genetic manipulation of Candida albicans is constrained by its diploid genome and asexual life cycle. Recessive mutations are not… (More)
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1992
1992
Spontaneous mutants requiring uracil were isolated from both varieties of Cryptococcus neoformans by plating on 5-fluoroorotic… (More)
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1991
1991
In the cellular slime mould Dictyostelium discoideum the two enzymatic activities of the pyrimidine pathway, orotidine-5… (More)
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1989
1989
Unlike mammalian cells, malarial parasites are completely dependent on de novo pyrimidine metabolism. Even though these parasites… (More)
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Highly Cited
1988
Highly Cited
1988
A system is described for gene disruption and replacement in Schizosaccharomyces pombe based on the homologous selectable marker… (More)
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Highly Cited
1987
Highly Cited
1987
5-FOA is an extremely useful reagent for the selection of Ura- cells amid a population of Ura+ cells. The selection is effective… (More)
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Highly Cited
1987
Highly Cited
1987
A homologous transformation system for the filamentous fungus Aspergillus niger has been developed, based on the orotidine-5… (More)
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