5-fluoro-2'-deoxycytidine

Known as: FdCyd, 5-fluoro-2-deoxycytidine, Cytidine, 2'-deoxy-5-fluoro- 
An antimetabolite consisting of a fluorinated pyrimidine analog with potential antineoplastic activity. As a prodrug, 5-fluoro-2-deoxycytidine is… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1959-2016
02419592016

Papers overview

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2010
2010
In vivo, the DNA methyltransferase inhibitor, 5-fluoro-2′-deoxycytidine (FdCyd, NSC-48006), is rapidly converted to its unwanted… (More)
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2007
2007
Although the DNA methyltransferase inhibitor 5-fluoro-2′-deoxycytidine (FdCyd), is being evaluated clinically, it must be… (More)
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2006
2006
PURPOSE In vivo, 5-fluoro-2'-deoxycytidine (FdCyd) is rapidly and sequentially converted to 5-fluoro-2'-deoxyuridine, 5… (More)
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Highly Cited
2005
Highly Cited
2005
DNA cytosine methylation plays a considerable role in normal development, gene regulation, and carcinogenesis. Hypermethylation… (More)
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1993
1993
The product of the dcm gene is the only DNA cytosine-C5 methyltransferase of Escherichia coli K-12; it catalyses transfer of a… (More)
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1992
1992
2'-Deoxyoligonucleotides with 5-fluorocytosine residues incorporated at specific positions of the nucleotide sequence are tools… (More)
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1991
1991
The overproduction, purification, and determination of the active-site catalytic nucleophile of the DNA (cytosine-5… (More)
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1987
1987
The metabolic products formed and incorporated into the nucleic acids (RNA and DNA) of mice bearing Lewis lung carcinoma (LLC… (More)
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1985
1985
The metabolism of 5-fluoro-2'-deoxycytidine (FdC) with and without tetrahydrouridine (H4U) or 2'-deoxytetrahydrouridine (dH4U… (More)
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1981
1981
Chemically synthesized 5-fluoro-2'-deoxyuridine 5'-triphosphate and 5-fluoro-2'-deoxycytidine 5'-triphosphate were used… (More)
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