5-carboxylcytosine

 
National Institutes of Health

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Review
2017
Review
2017
In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively reversed to unmodified cytosine (C) through TET… (More)
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Highly Cited
2013
Highly Cited
2013
Tet proteins oxidize 5-methylcytosine (mC) to generate 5-hydroxymethyl (hmC), 5-formyl (fC), and 5-carboxylcytosine (caC). The… (More)
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Highly Cited
2013
Highly Cited
2013
The TET (ten–eleven translocation) family of α-ketoglutarate (α-KG)-dependent dioxygenases catalyzes the sequential oxidation of… (More)
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Highly Cited
2012
Highly Cited
2012
Human thymine DNA glycosylase (hTDG) efficiently excises 5-carboxylcytosine (5caC), a key oxidation product of 5-methylcytosine… (More)
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Highly Cited
2011
Highly Cited
2011
The prevalent DNA modification in higher organisms is the methylation of cytosine to 5-methylcytosine (5mC), which is partially… (More)
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Highly Cited
2011
Highly Cited
2011
5-methylcytosine (5mC) in DNA plays an important role in gene expression, genomic imprinting, and suppression of transposable… (More)
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Highly Cited
2011
Highly Cited
2011
Thymine DNA glycosylase (TDG) excises T from G·T mispairs and is thought to initiate base excision repair (BER) of deaminated 5… (More)
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Review
2011
Review
2011
Ten-eleven translocation 1-3 (Tet1-3) proteins have recently been discovered in mammalian cells to be members of a family of DNA… (More)
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Highly Cited
2011
Highly Cited
2011
Although global erasure of DNA methylation has been observed in zygotes and primordial germ cells, the responsible enzyme(s) have… (More)
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Highly Cited
2010
Highly Cited
2010
5-Hydroxymethylcytosine (hmC) was recently detected as the sixth base in mammalian tissue at so far controversial levels. The… (More)
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