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5-aminoisoquinolinone
Known as:
5-AIQ
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
Isoquinolines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
The role of poly(ADP-ribose) polymerase-1 inhibitor in carrageenan-induced lung inflammation in mice.
S. Ahmad
,
K. M. Zoheir
,
+6 authors
S. Attia
Molecular Immunology
2015
Corpus ID: 20174594
2014
2014
Poly(ADP-ribose) polymerase-1 inhibitor modulates T regulatory and IL-17 cells in the prevention of adjuvant induced arthritis in mice model.
S. Ahmad
,
K. M. Zoheir
,
S. Bakheet
,
A. Ashour
,
S. Attia
Cytokine
2014
Corpus ID: 19147191
Highly Cited
2009
Highly Cited
2009
Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor.
A. Lord
,
M. Mahon
,
M. D. Lloyd
,
M. Threadgill
Journal of Medicinal Chemistry
2009
Corpus ID: 8095423
Poly(ADP-ribose)polymerase-1 is an important target enzyme in drug design; inhibitors have a wide variety of therapeutic…
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2009
2009
Inhibition of matrix metalloproteinase-2 by PARP inhibitors.
A. Nicolescu
,
A. Holt
,
A. Kandasamy
,
P. Pacher
,
R. Schulz
Biochemical and Biophysical Research…
2009
Corpus ID: 13771259
Review
2005
Review
2005
Poly(ADP-ribose)polymerase inhibition - where now?
E. Woon
,
M. Threadgill
Current Medicinal Chemistry
2005
Corpus ID: 27416424
The poly(ADP-ribose)polymerases (PARPs) catalyse the transfer of ADP-ribose units from the substrate NAD(+) to acceptor proteins…
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2005
2005
Effect of poly(ADP-ribosyl)ation inhibitors on the genotoxic effects of the boron neutron capture reaction.
N. Oliveira
,
M. Castro
,
+4 authors
J. Rueff
Mutation research
2005
Corpus ID: 27834890
Highly Cited
2004
Highly Cited
2004
5-Aminoisoquinolinone reduces renal injury and dysfunction caused by experimental ischemia/reperfusion.
P. Chatterjee
,
B. E. Chatterjee
,
+8 authors
C. Thiemermann
Kidney International
2004
Corpus ID: 43027511
BACKGROUND Poly (ADP-ribose) polymerase (PARP), a nuclear enzyme activated by strand breaks in DNA, plays an important role in…
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2002
2002
The novel PARP inhibitor 5-aminoisoquinolinone reduces the liver injury caused by ischemia and reperfusion in the rat.
H. Mota-Filipe
,
B. Sepodes
,
M. McDonald
,
S. Cuzzocrea
,
R. Pinto
,
C. Thiemermann
Medical Science Monitor
2002
Corpus ID: 11996842
BACKGROUND This study was designed to investigate the effects of 5-aminoisoquinolinone (5-AIQ), a water-soluble potent inhibitor…
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2001
2001
Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury.
S. Cuzzocrea
,
M. McDonald
,
+5 authors
C. Thiemermann
Biochemical Pharmacology
2001
Corpus ID: 26002735
Poly (ADP-ribose) polymerase (PARP), a nuclear enzyme activated by strand breaks in DNA, plays an important role in the tissue…
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Highly Cited
2000
Highly Cited
2000
Effects of 5‐aminoisoquinolinone, a water‐soluble, potent inhibitor of the activity of poly (ADP‐ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock
M. McDonald
,
H. Mota-Filipe
,
+4 authors
C. Thiemermann
British Journal of Pharmacology
2000
Corpus ID: 243589
Poly (ADP‐ribose) synthetase (PARP) is a nuclear enzyme activated by strand breaks in DNA, which are caused inter alia by…
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