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5-(N,N-hexamethylene)amiloride

Known as: 3-amino-6-chloro-5-(1-homopiperidyl)-N-(diaminomethylene)pyrazinecarboxamide, hexamethyleneamiloride, HMA-5 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

AmilorideAntineoplastic Agents
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Viral Membrane Channels: Role and Function in the Virus Life Cycle
Viroporins are small, hydrophobic trans-membrane viral proteins that oligomerize to form hydrophilic pores in the host cell… 
2014
2014
Docking assay of small molecule antivirals to p7 of HCV
Highly Cited
2010
Highly Cited
2010
Amiloride‐sensitive channels are a major contributor to mechanotransduction in mammalian muscle spindles
We investigated whether channels of the epithelial sodium/amiloride‐sensitive degenerin (ENaC/DEG) family are a major contributor… 
Highly Cited
2002
Highly Cited
2002
Amiloride derivatives block ion channel activity and enhancement of virus-like particle budding caused by HIV-1 protein Vpu
Abstract The Vpu protein of human immunodeficiency virus type 1 forms cation-selective ion channels and enhances the process of… 
Highly Cited
2001
Highly Cited
2001
Characterization of stretch-activated cation current in coronary smooth muscle cells.
Stretch-activated ion currents were recorded from vascular smooth muscle (VSM) after enzymatic isolation of single cells from… 
1999
1999
Na+ :H+ exchange inhibition induces intracellular acidosis and differentially impairs cell growth and viability of human and rat hepatocarcinoma cells.
Highly Cited
1995
Highly Cited
1995
Na+/H+ and Na+/Ca2+ exchange in regulation of [Na+]i and [Ca2+]i during metabolic inhibition.
The relationships among intracellular Na+ and Ca2+ concentrations ([Na+]i and [Ca2+]i, respectively) and cell morphology were… 
Highly Cited
1995
Highly Cited
1995
Role of Na-H exchangers and vacuolar H+ pumps in intracellular pH regulation in neonatal rat osteoclasts
Osteoclasts resorb bone by pumping of H+ into a compartment between the cell and the bone surface. Intracellular pH (pHi… 
1994
1994
The role of Na+/H+ exchange and the Na+/K+ pump in the regulation of [Na+]i during metabolic inhibition in guinea pig myocytes.
To investigate the mechanisms of Na+ loading during metabolic inhibition (MI), [Na+]i and pHi were measured in quiescent guinea… 
Highly Cited
1993
Highly Cited
1993
Sodium‐Dependent Antiporters in Choroid Plexus Epithelial Cultures from Rabbit
Abstract: The mechanism of recovery from an acid load in primary cultures of rabbit choroid plexus epithelium (CPE) was examined… 
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