5,6-Dihydroxytryptamine

Known as: 5,6-Dihydroxytryptamine [Chemical/Ingredient], 5,6 Dihydroxytryptamine, 1H-Indole-5,6-diol, 3-(2-aminoethyl)- 
Tryptamine substituted with two hydroxyl groups in positions 5 and 6. It is a neurotoxic serotonin analog that destroys serotonergic neurons… (More)
National Institutes of Health

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11 relations

Narrower (3)

4-methyl-5,6-dihydroxytryptamine5,7-dihydroxytryptamine creatinine7-methyl-5,6-dihydroxytryptamine
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Broader (1)

Serotonin Agents

Papers overview

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1992
1992
Ultrastructural, biochemical and electrophysiological changes induced by 5,6-dihydroxytryptamine in the CNS of the snail Helix pomatia L.
The serotonin neurotoxin, 5,6-dihydroxytryptamine (5,6-DHT), was injected into the body cavity of snails. Changes induced in the… (More)
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1989
1989
Monosynaptic connections between serotonin-containing neurones labelled by 5,6-dihydroxytryptamine-induced pigmentation in the snail Helix pomatia L.
Microelectrophysiological experiments were carried out on in vivo 5,6-dihydroxytryptamine-induced pigment-labelled serotonin… (More)
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1987
1987
Endogenously produced 5,6-dihydroxytryptamine may mediate the neurotoxic effects of para-chloroamphetamine
Para-chloroamphetamine (PCA) has been used to deplete brain serotonin (5-HT) in numerous studies of serotonergic involvement in… (More)
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1987
1987
5,6-dihydroxytryptamine, a serotonergic neutotoxin, is formed endogenously in the rat brain
Methamphetamine (MA) in high doses produces long-term toxic effects on the serotonergic system in the rat brain, including… (More)
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1987
1987
Morphological changes induced in turtle retinal neurons by exposure to 6-hydroxydopamine and 5,6-dihydroxytryptamine.
Following intraocular injection of the dopamine neurotoxin 6-hydroxydopamine (10-50 micrograms on two successive days in a Ringer… (More)
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1985
1985
Changes in nociception after lesions of descending serotonergic pathways induced with 5,6-dihydroxytryptamine: Different effects in the formalin and tail-flick tests
Intrathecal administration of 5,6-dihydroxytryptamine (5,6-DHT) in mice selectively lesioned descending serotonergic pathways… (More)
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1984
1984
Effect of local 5,6-dihydroxytryptamine on the rat olfactory bulb responsiveness during wakefulness and sleep.
This study investigated a possible participation of the centrifugal serotonergic (5-HT) innervation of the olfactory bulb (OB) in… (More)
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1972
1972
Evidence for a degeneration of indoleamine containing nerve terminals in rat brain, induced by 5,6-dihydroxytryptamine
5,6-dihydroxytryptamine (5,6-DHT) has been found to induce a substantial degree of “chemical degeneration” of indoleamine… (More)
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1972
1972
Chemical degeneration of indolamine axons in rat brain by 5,6-dihydroxytryptamine
Evidence has been obtained by electron microscopy of a direct cytotoxic effect of intraventricularly administered 5,6… (More)
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1972
1972
Mechanism of pressor effect of 5,6-dihydroxytryptamine in pithed rats
5,6-dihydroxytryptamine (5,6-DHT) — a neurotoxic drug causing a chemical degeneration of 5-hydroxytryptamine (5-HT) neurones in… (More)
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