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5,6-Dihydroxytryptamine

Known as: 5,6-Dihydroxytryptamine [Chemical/Ingredient], 5,6 Dihydroxytryptamine, 1H-Indole-5,6-diol, 3-(2-aminoethyl)- 
Tryptamine substituted with two hydroxyl groups in positions 5 and 6. It is a neurotoxic serotonin analog that destroys serotonergic neurons… 
National Institutes of Health

Related topics

Related topics

11 relations

Narrower (3)

4-methyl-5,6-dihydroxytryptamine5,7-dihydroxytryptamine creatinine7-methyl-5,6-dihydroxytryptamine
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Broader (1)

Serotonin Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1987
Highly Cited
1987
Release of substance P from the cat spinal cord.
1. The present experiments examine the physiology and pharmacology of the release of substance P‐like immunoreactivity (SP‐l.i… 
Highly Cited
1985
Highly Cited
1985
Changes in nociception after lesions of descending serotonergic pathways induced with 5,6-dihydroxytryptamine Different effects in the formalin and tail-flick tests
Intrathecal administration of 5,6-dihydroxytryptamine (5,6-DHT) in mice selectively lesioned descending serotonergic pathways… 
Highly Cited
1982
Highly Cited
1982
Changes in sensitivity to intrathecal norepinephrine and serotonin after 6-hydroxydopamine (6-OHDA), 5,6-dihydroxytryptamine (5,6-DHT) or repeated monoamine administration.
  • J. Howe, T. Yaksh
  • The Journal of pharmacology and experimental…
  • 1982
  • Corpus ID: 34284831
The behaviorally defined analgesia evoked by direct application of norepinephrine (NE) or serotonin (5-HT) into the rat spinal… 
Highly Cited
1980
Highly Cited
1980
Mechanisms of regrowth in the bulbospinal serotonin system following 5,6-dihydroxytryptamine induced axotomy. II. Fluorescence histochemical observations
Abstract The degenerative and regenerative processes following 75 μg 5,6-dihydroxytryptamine (5,6-DHT) have been investigated in… 
Highly Cited
1975
Highly Cited
1975
Hippocampal innervation by serotonin neurons of the midbrain raphe in the rat
The organization of the brainstem serotonin neuron projection to the hippocampal formation was analyzed in the rat. This… 
Highly Cited
1974
Highly Cited
1974
Functional regeneration of 5-hydroxytryptamine nerve terminals in the rat spinal cord following 5, 6-dihydroxytryptamine induced degeneration.
Abstract (1) Adult male rats were injected with 50 μg of 5,6-dihydroxytryptamine (5,6-HT) into the left lateral ventricle. The… 
Highly Cited
1974
Highly Cited
1974
Biochemical and behavioural alterations following 5,6-dihydroxytryptamine administration into brain.
Abstract Administration of 75 μg 5,6-dihydroxytryptamine (5,6-DHT) intracisternally caused a prolonged reduction of brain… 
Highly Cited
1973
Highly Cited
1973
Axonal degeneration and regeneration of bulbo-spinal indolamine neurons after 5,6-dihydroxytryptamine treatment.
Abstract The cellular events induced by intraventricular injection of 5,6-dihydroxytryptamine (5,6-DHT) were studied with… 
Highly Cited
1972
Highly Cited
1972
EFFECTS OF 5,6‐DIHYDROXYTRYPTAMINE ON MONOAMINERGIC NEURONES IN THE CENTRAL NERVOUS SYSTEM OF THE RAT
—The injection of 50 μg of 5,6‐dihydroxytryptamine (5,6‐HT) into a lateral ventricle of the rat depleted the spinal cord and… 
Highly Cited
1971
Highly Cited
1971
Long-lasting selective depletion of brain serotonin by 5,6-dihydroxytryptamine.
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