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5,6,7,8-tetrahydrofolic acid

Known as: (6S)-Tetrahydrofolic acid, Tetrahydrofolic acid 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (3)

FolacinTetrahydrofolateschemical cofactor
TetrahydrofolateTetrahydrofolate:MCnc:Pt:Plas:Qn

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Antibiotic resistance breakers: can repurposed drugs fill the antibiotic discovery void?
  • David Brown
  • Nature Reviews Drug Discovery
  • 2015
    • Corpus ID: 22378623
Concern over antibiotic resistance is growing, and new classes of antibiotics, particularly against Gram-negative bacteria, are… Expand
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Highly Cited
1999
Highly Cited
1999
A validated liquid chromatographic method for determining folates in vegetables, milk powder, liver, and flour.
  • E. Konings
  • Journal of AOAC International
  • 1999
    • Corpus ID: 9787659
A liquid chromatographic (LC) method was elaborated for determining folates in foods. Folates were extracted by homogenizing in… Expand
Highly Cited
1991
Highly Cited
1991
ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.
N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N- methylamino]-2-thenoyl)-L-glutamic acid (ICI D1694) is a water… Expand
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Review
1967
Review
1967
Folic acid metabolism.
The mammalian folic acid cycle is a highly complex but crucial process for the transfer of one-carbon units to amino acids… Expand
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Highly Cited
1966
Highly Cited
1966
The mechanism of the condensation of formaldehyde with tetrahydrofolic acid.
Abstract The bell-shaped pH rate profile for the reaction of tetrahydrofolic acid with formaldehyde to form 5,10-methylene… Expand
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Highly Cited
1964
Highly Cited
1964
TYROSINE HYDROXYLASE. THE INITIAL STEP IN NOREPINEPHRINE BIOSYNTHESIS.
After demonstration of the decarboxylation of 3,4-dihydroxyphenylalanine (dopa)’ to dopamine (I), the pathway for biosynthesis of… Expand
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Review
1963
Review
1963
THE BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ACTION AND EFFECTS OF THE FOLIC ACID ANTAGONISTS.
Summary A brief survey of biochemical and pharmacological information on the action of the 4-amino folic acid antagonists is… Expand
Review
1963
Review
1963
MECHANISMS OF RESISTANCE TO ANTICANCER AGENTS.
Publisher Summary This chapter focuses on mechanisms of resistance to anticancer agents. Attention has been given to mechanisms… Expand
Highly Cited
1961
Highly Cited
1961
Relation of folic acid reductase to amethopterin resistance in cultured mammalian cells.
SUMMARY Two lines of cultured Sarcoma 180 cells resistant to amethop- terin have been studied. Resistance developed gradually in… Expand
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Highly Cited
1957
Highly Cited
1957
Enzymatic reduction of folic acid and dihydrofolic acid to tetrahydrofolic acid.
  • S. Futterman
  • The Journal of biological chemistry
  • 1957
    • Corpus ID: 747579
Earlier reports on the inactivation of FA’ in the presence of liver extracts indicated the supplements required (1, 2) and… Expand
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