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Concern over antibiotic resistance is growing, and new classes of antibiotics, particularly against Gram-negative bacteria, are… Expand A liquid chromatographic (LC) method was elaborated for determining folates in foods. Folates were extracted by homogenizing in… Expand N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N- methylamino]-2-thenoyl)-L-glutamic acid (ICI D1694) is a water… Expand The mammalian folic acid cycle is a highly complex but crucial process for the transfer of one-carbon units to amino acids… Expand Abstract The bell-shaped pH rate profile for the reaction of tetrahydrofolic acid with formaldehyde to form 5,10-methylene… Expand After demonstration of the decarboxylation of 3,4-dihydroxyphenylalanine (dopa)’ to dopamine (I), the pathway for biosynthesis of… Expand Summary A brief survey of biochemical and pharmacological information on the action of the 4-amino folic acid antagonists is… Expand Publisher Summary This chapter focuses on mechanisms of resistance to anticancer agents. Attention has been given to mechanisms… Expand SUMMARY Two lines of cultured Sarcoma 180 cells resistant to amethop- terin have been studied. Resistance developed gradually in… Expand Earlier reports on the inactivation of FA’ in the presence of liver extracts indicated the supplements required (1, 2) and… Expand