5'-fluoro-5'-deoxyadenosine

Fluorinases offer an environmentally friendly alternative for selective fluorination under mild conditions. However, their… Expand

Streptomyces cattleya DSM 46488 is unusual in its ability to biosynthesise fluorine containing natural products, where it can… Expand

(3R,4S)-5-Fluoro-5-deoxy-D-ribulose-1-phosphate (5-FDRulP) has been identified as the third fluorinated intermediate on the… Expand

A genomic library of Streptomyces cattleya was screened to isolate a gene cluster encoding enzymes responsible for the production… Expand

Synthesis of 5'-fluoro-5'-deoxyadenosine (5'-FDA) and structurally similar compounds is generally a poor yielding process. This… Expand

The C-F bond-forming step in the fluorinase, the only native fluorination enzyme characterized to date, has been studied. The… Expand

5'-Fluoro-5'-deoxyinosine (5'-FDI) is identified as an adventitious side product that accumulates in cell free incubations of SAM… Expand

The stereochemical course of the recently isolated fluorination enzyme from Streptomyces cattleya has been evaluated. The enzyme… Expand

5'-fluorodeoxyadenosine synthase, a C-F bond-forming enzyme, has been purified from Streptomyces cattleya. The enzyme mediates a… Expand

Organofluorine compounds are widely prepared throughout the chemicals industry, but their prepararion generally requires harsh… Expand