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5'-fluoro-5'-deoxyadenosine

Known as: 5'-FDA cpd 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Deoxyadenosines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Hydrogen-Bonded Homoleptic Fluoride-Diarylurea Complexes: Structure, Reactivity, and Coordinating Power.
Hydrogen bonding with fluoride is a key interaction encountered when analyzing the mode of action of 5'-fluoro-5'-deoxyadenosine… Expand
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2012
2012
Insights into fluorometabolite biosynthesis in Streptomyces cattleya DSM46488 through genome sequence and knockout mutants.
Streptomyces cattleya DSM 46488 is unusual in its ability to biosynthesise fluorine containing natural products, where it can… Expand
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2007
2007
The identification of (3R,4S)-5-fluoro-5-deoxy-D-ribulose-1-phosphate as an intermediate in fluorometabolite biosynthesis in Streptomyces cattleya.
(3R,4S)-5-Fluoro-5-deoxy-D-ribulose-1-phosphate (5-FDRulP) has been identified as the third fluorinated intermediate on the… Expand
Highly Cited
2006
Highly Cited
2006
The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A.
A genomic library of Streptomyces cattleya was screened to isolate a gene cluster encoding enzymes responsible for the production… Expand
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2005
2005
An improved synthesis of 5'-fluoro-5'-deoxyadenosines.
Synthesis of 5'-fluoro-5'-deoxyadenosine (5'-FDA) and structurally similar compounds is generally a poor yielding process. This… Expand
2005
2005
The identification of 5'-fluoro-5-deoxyinosine as a shunt product in cell free extracts of Streptomyces cattleya.
5'-Fluoro-5'-deoxyinosine (5'-FDI) is identified as an adventitious side product that accumulates in cell free incubations of SAM… Expand
Highly Cited
2005
Highly Cited
2005
Insight into enzymatic C-F bond formation from QM and QM/MM calculations.
The C-F bond-forming step in the fluorinase, the only native fluorination enzyme characterized to date, has been studied. The… Expand
Highly Cited
2004
Highly Cited
2004
Enzymatic Fluorination in Streptomyces cattleya Takes Place with an Inversion of Configuration Consistent with an SN2 Reaction Mechanism
The stereochemical course of the recently isolated fluorination enzyme from Streptomyces cattleya has been evaluated. The enzyme… Expand
Highly Cited
2003
Highly Cited
2003
Isolation and characterisation of 5′‐fluorodeoxyadenosine synthase, a fluorination enzyme from Streptomyces cattleya
5′‐Fluorodeoxyadenosine synthase, a C–F bond‐forming enzyme, has been purified from Streptomyces cattleya. The enzyme mediates a… Expand
2003
2003
Crystallization and X-ray diffraction of 5'-fluoro-5'-deoxyadenosine synthase, a fluorination enzyme from Streptomyces cattleya.
Organofluorine compounds are widely prepared throughout the chemicals industry, but their prepararion generally requires harsh… Expand
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