5'-3'-Exonucleases

Known as: 5'-3' Exonuclease, 5'-3'-Exonuclease, 5' 3' Exonucleases 
Five Prime-Three Prime Exonucleases specifically catalyze the hydrolysis of terminal phosphodiester bonds of nucleic acids. Human XRN1 and XRN2 are… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1977-2016
051019772016

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2010
2010
Termination of RNA polymerase II (RNAPII) transcription of protein-coding genes occurs downstream of cleavage/polyadenylation… (More)
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2006
Highly Cited
2006
As an important mode of suppressing gene expression, messenger RNAs containing an AU-rich element (ARE) in the 3' untranslated… (More)
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2003
Highly Cited
2003
Exonuclease 1 (Exo1) is a 5'-3' exonuclease that interacts with MutS and MutL homologs and has been implicated in the excision… (More)
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Highly Cited
2002
Highly Cited
2002
HeLa cytoplasmic extracts contain both 3'-5' and 5'-3' exonuclease activities that may play important roles in mRNA decay. Using… (More)
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Highly Cited
2002
Highly Cited
2002
We have cloned cDNAs for the human homologues of the yeast Dcp1 and Dcp2 factors involved in the major (5'-3') and NMD mRNA decay… (More)
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2002
2002
We isolated and characterized a new nuclease (NurA) exhibiting both single-stranded endonuclease activity and 5'-3' exonuclease… (More)
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1997
Highly Cited
1997
A two-hybrid screen was used to identify Saccharomyces cerevisiae genes encoding proteins that interact with MSH2. One gene was… (More)
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1997
Highly Cited
1997
We previously described a 5'-3' exonuclease required for recombination in vitro between linear DNA molecules with overlapping… (More)
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1996
1996
THE 5'-exonucleases are enzymes that are essential for DNA replication and repair1. As well as their exonucleolytic action… (More)
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1994
Highly Cited
1994
The repair of some types of DNA double-strand breaks is thought to proceed through DNA flap structure intermediates. A DNA flap… (More)
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