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4a-hydroxytetrahydrobiopterin dehydratase

Known as: pterin-4a-carbinolamine dehydratase, pterin-4alpha-carbinolamine dehydratase, dimerization cofactor of HNF-1alpha 
National Institutes of Health

Related topics

Related topics

4 relations
4a-hydroxytetrahydrobiopterin dehydratase activity

Broader (1)

Hydro-Lyases

Narrower (2)

PCBD1 protein, humanPcbd1 protein, mouse

Papers overview

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Highly Cited
2014
Highly Cited
2014
A protein with an inactive pterin-4a-carbinolamine dehydratase domain is required for Rubisco biogenesis in plants.
Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) plays a critical role in sustaining life by catalysis of carbon… 
Review
2011
Review
2011
Tetrahydrobiopterin: biochemistry and pathophysiology.
BH4 (6R-L-erythro-5,6,7,8-tetrahydrobiopterin) is an essential cofactor of a set of enzymes that are of central metabolic… 
Highly Cited
2009
Highly Cited
2009
Exhaustive analysis of BH4 and dopamine biosynthesis genes in patients with Dopa-responsive dystonia.
Dopa-responsive dystonia is a childhood-onset dystonic disorder, characterized by a dramatic response to low dose of L-Dopa. Dopa… 
Highly Cited
2005
Highly Cited
2005
International database of tetrahydrobiopterin deficiencies
SummaryApproximately 2% of newborns with hyperphenylalaninaemia are deficient in tetrahydrobiopterin. Selective screening must be… 
Highly Cited
2004
Highly Cited
2004
Activation/deactivation of acetylcholinesterase by H2O2: more evidence for oxidative stress in vitiligo.
Highly Cited
2002
Highly Cited
2002
HNF-1α G319S, a transactivation-deficient mutant, is associated with altered dynamics of diabetes onset in an Oji-Cree community
The prevalence of type 2 diabetes mellitus in the Oji-Cree of northwestern Ontario is the third highest in the world. A private… 
Review
2002
Review
2002
Disorders of tetrahydrobiopterin metabolism and their treatment.
  • H. Shintaku
  • Current drug metabolism
  • 2002
  • Corpus ID: 11743250
Tetrahydrobiopterin (BH4) deficiencies are disorders affecting phenylalanine metabolism in liver and neurotransmitters… 
Review
2000
Review
2000
Tetrahydrobiopterin biosynthesis, regeneration and functions.
Tetrahydrobiopterin (BH(4)) cofactor is essential for various processes, and is present in probably every cell or tissue of… 
Highly Cited
1999
Highly Cited
1999
Metabolic activation of dacarbazine by human cytochromes P450: the role of CYP1A1, CYP1A2, and CYP2E1.
Dacarbazine (DTIC), a widely used anticancer agent, is inactive until metabolized in the liver by cytochromes P450 to form the… 
Highly Cited
1989
Highly Cited
1989
Evidence for the formation of the 4a-carbinolamine during the tyrosine-dependent oxidation of tetrahydrobiopterin by rat liver phenylalanine hydroxylase.
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