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4SC-202

Known as: HDAC Inhibitor 4SC-202 
An orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic… Expand
National Institutes of Health

Papers overview

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2019
2019
BackgroundTargeting epigenetic modifiers is effective in cutaneous T cell lymphoma (CTCL). However, there is a need for further… Expand
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2018
2018
Aberrant activation of Hedgehog (HH)/GLI signaling is causally involved in numerous human malignancies, including basal cell… Expand
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2017
2017
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with a particularly dismal prognosis. Histone deacetylases… Expand
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2017
2017
In human cells, thousands of predominantly neuronal genes are regulated by the repressor element 1 (RE1)-silencing transcription… Expand
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2017
2017
This project involves an examination of the effect of the small molecule inhibitor 4SC-202 on the growth of the pediatric brain… Expand
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2016
2016
Histone deacetylase (HDAC) overactivity in colorectal cancer (CRC) promotes cancer progression. In the current study, we showed… Expand
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2016
2016
BackgroundTargeting of class I histone deacetylases (HDACs) exerts antineoplastic actions in various cancer types by modulation… Expand
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2016
2016
The aim of the present study is to investigate the potential anti-hepatocellular carcinoma (HCC) cell activity by 4SC-202, a… Expand
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2016
2016
11546Background: 4SC-202 is an orally available, small molecule clinical stage epigenetic modulator. Epigenetic modifiers are… Expand
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2014
2014
8559 Background: 4SC-202 is a specific inhibitor of protein deacetylases HDAC1, 2 and 3 and lysine specific demethylase LSD1… Expand
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