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4-phenyl-4-piperidinocyclohexanol

Known as: 1-(1-phenyl-4-hydroxycyclohexyl)piperidine, 4-phenyl-4-(1-piperidinyl)cyclohexanol 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Phencyclidine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1996
1996
Hair analysis for drugs of abuse XII. Determination of PCP and its major metabolites, PCHP and PPC, in rat hair after administration of PCP.
We developed an analytical method for the simultaneous detection of phencyclidine (PCP) and its metabolites, 4-phenyl-4… Expand
1994
1994
Effects of the major metabolite of phencyclidine, the trans isomer of 4-phenyl-4-(1-piperidinyl)cyclohexanol, on [3H]N-(1-[2-thienyl]cyclohexyl)-3,4-piperidine ([3H]TCP) binding and [3H]dopamine…
The major metabolite of phencyclidine (PCP), the trans isomer of 4-phenyl-4-(1-piperidinyl)cyclohexanol [(trans)-4-PPC… Expand
1994
1994
Behavioral effects of phencyclidine and its major metabolite, (trans)4-phenyl-4-(1-piperidinyl)cyclohexanol, in mice
To elucidate the biological activity of natural metabolites of phencyclidine (PCP), we examined the behavioral effects of a major… Expand
1987
1987
Doubtful role for phenycyclidine metabolites in PCP enhancement of QNB binding
In vivo administration of phencyclidine (PCP) has been shown to enhance the accumulation of intravenously administered 3H… Expand
1984
1984
Phencyclidine analogs and precursors: rotarod and lethal dose studies in the mouse.
A series of phencyclidine (PCP) related analogs, carbonitrile synthetic precursors and two monohydroxylated metabolites were… Expand
Highly Cited
1982
Highly Cited
1982
Phencyclidine disposition after intravenous and oral doses
[3H]‐Phencyclidine (PCP) hydrochloride was given in intravenous (0.1 or 1 mg) or oral (1 mg) doses to male subjects. After 1 mg… Expand
1982
1982
Chemical synthesis and molecular pharmacology of hydroxylated 1-(1-phenylcyclohexyl-piperidine derivatives.
The following monohydroxy derivatives of 1-(1-phenylcyclohexyl)piperidine (phencyclidine, PCP) were synthesized: o-, m-, and p… Expand
1981
1981
Phencyclidine metabolism: resolution, structure, and biological activity of the isomers of the hydroxy metabolite, 4-phenyl-4-(1-piperidinyl)cyclohexanol.
One of the major biotransformation pathways in the metabolism of phencyclidine is hydroxylation at C-4 of the cyclohexane ring to… Expand
1981
1981
Metabolism of phencyclidine by microorganisms.
A number of microorganisms were screened for their ability to metabolize phencyclidine. Two microorganisms, Beauveria… Expand
1981
1981
The metabolism of phencyclidine by rabbit liver preparations.
The in vitro metabolism of phencyclidine by rabbit liver 9000g supernatant fraction produces primarily three known hydroxylated… Expand
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