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4-phenyl-4-piperidinocyclohexanol

Known as: 1-(1-phenyl-4-hydroxycyclohexyl)piperidine, 4-phenyl-4-(1-piperidinyl)cyclohexanol 
 
National Institutes of Health

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2 relations

Broader (1)

Phencyclidine
analogs & derivatives

Papers overview

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1996
1996
Hair analysis for drugs of abuse XII. Determination of PCP and its major metabolites, PCHP and PPC, in rat hair after administration of PCP.
We developed an analytical method for the simultaneous detection of phencyclidine (PCP) and its metabolites, 4-phenyl-4… Expand
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1994
1994
Behavioral effects of phencyclidine and its major metabolite, (trans)4-phenyl-4-(1-piperidinyl)cyclohexanol, in mice
To elucidate the biological activity of natural metabolites of phencyclidine (PCP), we examined the behavioral effects of a major… Expand
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1994
1994
Effects of the major metabolite of phencyclidine, the trans isomer of 4-phenyl-4-(1-piperidinyl)cyclohexanol, on [3H]N-(1-[2-thienyl]cyclohexyl)-3,4-piperidine ([3H]TCP) binding and [3H]dopamine…
The major metabolite of phencyclidine (PCP), the trans isomer of 4-phenyl-4-(1-piperidinyl)cyclohexanol [(trans)-4-PPC… Expand
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1989
1989
Some factors affecting phencyclidine biotransformation by human liver and placenta.
Samples of human liver and placenta microsomes were analyzed for their in vitro hydroxylation capabilities using phencyclidine… Expand
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1987
1987
Doubtful role for phenycyclidine metabolites in PCP enhancement of QNB binding
In vivo administration of phencyclidine (PCP) has been shown to enhance the accumulation of intravenously administered 3H… Expand
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1986
1986
Metabolic interactions of phencyclidine (PCP) and delta 9-tetrahydrocannabinol (THC) in the rat.
The in vitro effects of THC on the metabolism of PCP by rat liver were determined. Samples containing 1 mM PCP were incubated for… Expand
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1984
1984
Phencyclidine analogs and precursors: rotarod and lethal dose studies in the mouse.
A series of phencyclidine (PCP) related analogs, carbonitrile synthetic precursors and two monohydroxylated metabolites were… Expand
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1982
1982
Phencyclidine disposition after intravenous and oral doses.
[3H]-Phencyclidine (PCP) hydrochloride was given in intravenous (0.1 or 1 mg) or oral (1 mg) doses to male subjects. After 1 mg… Expand
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1982
1982
Chemical synthesis and molecular pharmacology of hydroxylated 1-(1-phenylcyclohexyl-piperidine derivatives.
The following monohydroxy derivatives of 1-(1-phenylcyclohexyl)piperidine (phencyclidine, PCP) were synthesized: o-, m-, and p… Expand
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1981
1981
Phencyclidine metabolism: resolution, structure, and biological activity of the isomers of the hydroxy metabolite, 4-phenyl-4-(1-piperidinyl)cyclohexanol.
One of the major biotransformation pathways in the metabolism of phencyclidine is hydroxylation at C-4 of the cyclohexane ring to… Expand
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