4-phenyl-4-piperidinocyclohexanol

The major metabolite of phencyclidine (PCP), the trans isomer of 4-phenyl-4-(1-piperidinyl)cyclohexanol [(trans)-4-PPC… (More)

To elucidate the biological activity of natural metabolites of phencyclidine (PCP), we examined the behavioral effects of a major… (More)

Samples of human liver and placenta microsomes were analyzed for their in vitro hydroxylation capabilities using phencyclidine… (More)

In vivo administration of phencyclidine (PCP) has been shown to enhance the accumulation of intravenously administered 3H… (More)

The in vitro effects of THC on the metabolism of PCP by rat liver were determined. Samples containing 1 mM PCP were incubated for… (More)

A series of phencyclidine (PCP) related analogs, carbonitrile synthetic precursors and two monohydroxylated metabolites were… (More)

[3H]-Phencyclidine (PCP) hydrochloride was given in intravenous (0.1 or 1 mg) or oral (1 mg) doses to male subjects. After 1 mg… (More)

The following monohydroxy derivatives of 1-(1-phenylcyclohexyl)piperidine (phencyclidine, PCP) were synthesized: o-, m-, and p… (More)

A number of microorganisms were screened for their ability to metabolize phencyclidine. Two microorganisms, Beauveria… (More)

One of the major biotransformation pathways in the metabolism of phencyclidine is hydroxylation at C-4 of the cyclohexane ring to… (More)