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4-ipomeanol

Known as: 1-Pentanone, 1-(3-furanyl)-4-hydroxy-, 1-(3-furyl)-4-hydroxypentanone, 1-(3-furanyl)-4-hydroxy-1-pentanone 
A natural toxic furan isolated from a fungus-infected sweet potato (Ipomoea batatas) with potential antineoplastic activity. Ipomeanol is activated… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (4)

Antineoplastic AgentsPlant alkaloidTerpenesplant poison

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Metabolism of furans in vitro: ipomeanine and 4-ipomeanol.
Ipomeanine (IPN), 4-ipomeanol (4-IPO), 1-ipomeanol (1-IPO), and 1,4-ipomeadiol (DIOL) are toxic 3-substituted furans found in… 
2004
2004
DETECTION OF GLUTATHIONE CONJUGATES DERIVED FROM 4-IPOMEANOL METABOLISM IN BILE OF RATS BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY
Earlier studies postulated that bioactivation of 4-ipomeanol by cytochrome P450 enzymes may occur through oxidation of its furan… 
1997
1997
DNA adducts of heterocyclic amines: formation, removal and inhibition by dietary components.
1995
1995
Inhibitory effect of dietary 4-ipomeanol on DNA adduct formation by the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in male CDF1 mice.
The food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) is carcinogenic in the CDF1 mouse liver, lungs and stomach. IQ is… 
1991
1991
The use of hepatocytes cultured from inducer-treated rats in the detection of cytochrome P-450-mediated cytotoxicity.
1990
1990
Reactive metabolite formation catalysed by cytochrome P-450j.
1987
1987
Preclinical toxicology studies of 4-ipomeanol: a novel candidate for clinical evaluation in lung cancer.
4-Ipomeanol (ipomeanol) is being developed as a potential antitumor agent to treat lung cancer. Ipomeanol produced a dose-related… 
1985
1985
Pulmonary endothelial and bronchiolar epithelial lesions induced by 4-ipomeanol in mice.
The morphogenesis of pulmonary edema and bronchiolar injury induced by the toxic furan, 4-ipomeanol, was studied by combined… 
Review
1984
Review
1984
Alveolar type II and Clara cells: isolation and xenobiotic metabolism.
This paper describes one isolation procedure for two pulmonary cell types and discusses how these cells are being used for… 
Review
1975
Review
1975
Ipomeamarone, a toxic furanoterpenoid in sweet potatoes (Ipomea batatas) in the United Kingdom.
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