4-ipomeanol

Known as: 1-Pentanone, 1-(3-furanyl)-4-hydroxy-, 1-(3-furyl)-4-hydroxypentanone, 1-(3-furanyl)-4-hydroxy-1-pentanone 
A natural toxic furan isolated from a fungus-infected sweet potato (Ipomoea batatas) with potential antineoplastic activity. Ipomeanol is activated… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1972-2017
051019722017

Papers overview

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2006
2006
Ipomeanine (IPN), 4-ipomeanol (4-IPO), 1-ipomeanol (1-IPO), and 1,4-ipomeadiol (DIOL) are toxic 3-substituted furans found in… (More)
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2004
2004
Earlier phase I and II clinical studies showed that 4-ipomeanol produced selective hepatotoxicity. To investigate the mechanism… (More)
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1998
1998
Nonciliated bronchiolar (Clara) cells metabolize environmental toxicants, are progenitor cells during development, and… (More)
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1998
1998
Vector-mediated transfer of prodrug-activating genes provides a promising means of cancer gene therapy. In a search for more… (More)
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1994
1994
The bronchiolar Clara cell is one of the primary targets in adult mammals for environmental contaminants metabolized by… (More)
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1993
1993
Inhibition of pulmonary CYP4B1 activity by pretreatment of rats with p-xylene decreased the ability of lung microsomes to N… (More)
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1991
1991
4-Ipomeanol is a pulmonary toxin in cattle and rodents that is metabolically activated by cytochromes P-450 (P-450s). P-450… (More)
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1991
1991
Previous research has demonstrated that 4-ipomeanol toxicosis can enhance the severity of para-influenza virus-induced pneumonia… (More)
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1986
1986
In the normal lungs of many animal species, 4-ipomeanol is transformed to a highly reactive metabolite preferentially in… (More)
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1978
1978
Cattle given intraruminal administration of 4-ipomeanol, a furanoterpenoid originally obtained from sweet potatoes infected with… (More)
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