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4-ipomeanol

Known as: 1-Pentanone, 1-(3-furanyl)-4-hydroxy-, 1-(3-furyl)-4-hydroxypentanone, 1-(3-furanyl)-4-hydroxy-1-pentanone 
A natural toxic furan isolated from a fungus-infected sweet potato (Ipomoea batatas) with potential antineoplastic activity. Ipomeanol is activated… Expand
National Institutes of Health

Papers overview

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2014
2014
Mammalian CYP4B1 enzymes are cytochrome P450 mono-oxygenases that are responsible for the bioactivation of several exogenous pro… Expand
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2005
2005
4-Ipomeanol (IPO) is a pneumotoxin that is bioactivated to a reactive intermediate that binds to DNA and other cellular… Expand
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Highly Cited
1999
Highly Cited
1999
The 16 kDa Clara cell protein (CC16), an abundant component of airway secretions, has recently been proposed in humans as a… Expand
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1998
1998
Vector-mediated transfer of prodrug-activating genes provides a promising means of cancer gene therapy. In a search for more… Expand
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1998
1998
Nonciliated bronchiolar (Clara) cells metabolize environmental toxicants, are progenitor cells during development, and… Expand
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1993
1993
Inhibition of pulmonary CYP4B1 activity by pretreatment of rats with p-xylene decreased the ability of lung microsomes to N… Expand
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1983
1983
The naturally occurring compound, 4-ipomeanol (IPO, 1-[3-furyl]-4-hydroxy-1-pentanone), selectively damages the nonciliated… Expand
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1982
1982
The metabolism and covalent binding of 4-ipomeanol (IPO), a pulmonary toxin, were investigated in pulmonary cells isolated from… Expand
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1979
1979
Abstract The organ specificities of the in vivo covalent binding of 4-ipomeanol were closely correlated with the patterns of… Expand
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Highly Cited
1977
Highly Cited
1977
THE cellular localisation of pulmonary mixed-function oxidase (MFO) activity has aroused considerable interest, especially… Expand
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