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4-ipomeanol

Known as: 1-Pentanone, 1-(3-furanyl)-4-hydroxy-, 1-(3-furyl)-4-hydroxypentanone, 1-(3-furanyl)-4-hydroxy-1-pentanone 
A natural toxic furan isolated from a fungus-infected sweet potato (Ipomoea batatas) with potential antineoplastic activity. Ipomeanol is activated… 
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
4-Ipomeanol (IPO) is a pneumotoxin that is bioactivated to a reactive intermediate that binds to DNA and other cellular… 
Highly Cited
1998
Highly Cited
1998
Vector-mediated transfer of prodrug-activating genes provides a promising means of cancer gene therapy. In a search for more… 
Highly Cited
1991
Highly Cited
1991
4-Ipomeanol is a pulmonary toxin in cattle and rodents that is metabolically activated by cytochromes P-450 (P-450s). P-450… 
Review
1989
Review
1989
Review
1989
Review
1989
4-Ipomeanol (IPO) is the first agent to undergo preclinical development at the National Cancer Institute (NCI) based principally… 
Highly Cited
1982
Highly Cited
1982
The metabolism and covalent binding of 4-ipomeanol (IPO), a pulmonary toxin, were investigated in pulmonary cells isolated from… 
Highly Cited
1978
Highly Cited
1978
  • M. Boyd, L. Burka
  • The Journal of pharmacology and experimental…
  • 1978
  • Corpus ID: 7730013
The pulmonary toxin, 4-ipomeanol, selectively alkylates the lungs of rats. Time-course and dose-response studies demonstrate a… 
Highly Cited
1978
Highly Cited
1978
Rat lung and liver microsomes mediated the biotransformation of the pulmonary toxin, 4-ipomeanol, to an alkylating metabolite… 
Highly Cited
1977
Highly Cited
1977
  • M. Boyd
  • Nature
  • 1977
  • Corpus ID: 4177189
THE cellular localisation of pulmonary mixed-function oxidase (MFO) activity has aroused considerable interest, especially…