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4-Ipomeanol (IPO) is a pneumotoxin that is bioactivated to a reactive intermediate that binds to DNA and other cellular… Expand Vector-mediated transfer of prodrug-activating genes provides a promising means of cancer gene therapy. In a search for more… Expand 4-Ipomeanol is a pulmonary toxin in cattle and rodents that is metabolically activated by cytochromes P-450 (P-450s). P-450… Expand Abstract The formation of highly reactive metabolites from 4-ipomeanol, a selective lung toxin in rodents and other mammals and a… Expand The metabolism and covalent binding of 4-ipomeanol (IPO), a pulmonary toxin, were investigated in pulmonary cells isolated from… Expand Abstract The organ specificities of the in vivo covalent binding of 4-ipomeanol were closely correlated with the patterns of… Expand The pulmonary toxin, 4-ipomeanol, selectively alkylates the lungs of rats. Time-course and dose-response studies demonstrate a… Expand THE cellular localisation of pulmonary mixed-function oxidase (MFO) activity has aroused considerable interest, especially… Expand Many xenobiotics produce hepatic injury due to their metabolism in the liver to highly reactive electrophile intermediates which… Expand Abstract 4-Ipomeanol [1-(3-furyl)-4-hydroxypentanone] is a poisonous metabolite produced in the mold-damaged sweet potato… Expand