Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

4-ipomeanol

Known as: 1-Pentanone, 1-(3-furanyl)-4-hydroxy-, 1-(3-furyl)-4-hydroxypentanone, 1-(3-furanyl)-4-hydroxy-1-pentanone 
A natural toxic furan isolated from a fungus-infected sweet potato (Ipomoea batatas) with potential antineoplastic activity. Ipomeanol is activated… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
4-Ipomeanol (IPO) is a pneumotoxin that is bioactivated to a reactive intermediate that binds to DNA and other cellular… Expand
Highly Cited
1998
Highly Cited
1998
Vector-mediated transfer of prodrug-activating genes provides a promising means of cancer gene therapy. In a search for more… Expand
Highly Cited
1991
Highly Cited
1991
4-Ipomeanol is a pulmonary toxin in cattle and rodents that is metabolically activated by cytochromes P-450 (P-450s). P-450… Expand
  • table 1
  • table 2
  • table 3
1982
1982
Abstract The formation of highly reactive metabolites from 4-ipomeanol, a selective lung toxin in rodents and other mammals and a… Expand
Highly Cited
1982
Highly Cited
1982
The metabolism and covalent binding of 4-ipomeanol (IPO), a pulmonary toxin, were investigated in pulmonary cells isolated from… Expand
Highly Cited
1979
Highly Cited
1979
Abstract The organ specificities of the in vivo covalent binding of 4-ipomeanol were closely correlated with the patterns of… Expand
Highly Cited
1978
Highly Cited
1978
  • M. Boyd, L. Burka
  • The Journal of pharmacology and experimental…
  • 1978
  • Corpus ID: 7730013
The pulmonary toxin, 4-ipomeanol, selectively alkylates the lungs of rats. Time-course and dose-response studies demonstrate a… Expand
Highly Cited
1977
Highly Cited
1977
  • M. Boyd
  • Nature
  • 1977
  • Corpus ID: 4177189
THE cellular localisation of pulmonary mixed-function oxidase (MFO) activity has aroused considerable interest, especially… Expand
Highly Cited
1976
Highly Cited
1976
  • M. Boyd
  • Environmental health perspectives
  • 1976
  • Corpus ID: 8984389
Many xenobiotics produce hepatic injury due to their metabolism in the liver to highly reactive electrophile intermediates which… Expand
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • table 2
1975
1975
Abstract 4-Ipomeanol [1-(3-furyl)-4-hydroxypentanone] is a poisonous metabolite produced in the mold-damaged sweet potato… Expand