4-hydroxytoremifene
National Institutes of Health
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While estrogen receptor (ER)-targeted therapeutics have clearly been a success in the treatment of breast cancer, the orphan…
SummaryA multicenter phase I pharmacokineticstudy of a new triphenylethylene antiestrogen, toremifene, was examined in 70…
SummaryToremifene, a new antiestrogenic antitumor compound, has several biologically active metabolites. The hormonal effects of…
The antiestrogen, tamoxifen, has been extensively used in the treatment and prevention of breast cancer. Although tamoxifen…
The in vitro metabolism of toremifene has been studied in liver microsomal preparations from rat, mouse and human sources using…
Tamoxifen remains the endocrine therapy of choice in the treatment of all stages of hormone-dependent breast cancer. However…
Tamoxifen is widely prescribed for the treatment of hormone-dependent breast cancer, and it has recently been approved by the…
Abstract The aim of the present study was to investigate antioxidativity of the triphenylethylene antiestrogen toremifene…