4-hydroxytoremifene

While estrogen receptor (ER)-targeted therapeutics have clearly been a success in the treatment of breast cancer, the orphan… Expand

SummaryA multicenter phase I pharmacokineticstudy of a new triphenylethylene antiestrogen, toremifene, was examined in 70… Expand

Estrogen-related receptor gamma (ERRgamma) is an orphan nuclear receptor lacking identified natural ligands. We have addressed… Expand

SummaryToremifene, a new antiestrogenic antitumor compound, has several biologically active metabolites. The hormonal effects of… Expand

The antiestrogen, tamoxifen, has been extensively used in the treatment and prevention of breast cancer. Although tamoxifen… Expand

The in vitro metabolism of toremifene has been studied in liver microsomal preparations from rat, mouse and human sources using… Expand

Tamoxifen remains the endocrine therapy of choice in the treatment of all stages of hormone-dependent breast cancer. However… Expand

Tamoxifen is widely prescribed for the treatment of hormone-dependent breast cancer, and it has recently been approved by the… Expand

Abstract The aim of the present study was to investigate antioxidativity of the triphenylethylene antiestrogen toremifene… Expand

Tamoxifen and its analogues 4-hydroxytamoxifen, toremifene, 4-hydroxytoremifene, clomifene and droloxifene were tested for… Expand