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4-hydroxydebrisoquin

Known as: 4-hydroxydebrisoquine, Ro 03,7594 
National Institutes of Health

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2 relations

Broader (1)

Debrisoquin
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2000
2000
Enantioselectivity of debrisoquine 4-hydroxylation in Brazilian Caucasian hypertensive patients phenotyped as extensive metabolizers.
1997
1997
Characterization of stereoselectivity and genetic polymorphism of the debrisoquine hydroxylation in man via analysis of urinary debrisoquine and 4‐hydroxydebrisoquine by capillary electrophoresis
Using capillary zone electrophoresis with a phosphate buffer at pH 2.5 containing 50 mM heptakis‐(2,3,6‐tri‐O‐methyl)‐β‐CD as… 
1997
1997
Separation and quantitation of debrisoquine and 4-hydroxydebrisoquine in human urine by capillary electrophoresis and high-performance liquid chromatography.
1997
1997
In vitro metabolism of indinavir in the human fetal liver microsomes.
In vitro microsomal formation of primary metabolites of indinavir (CRIXIVAN, MK-0639, L-735,524), an HIV protease inhibitor, were… 
1988
1988
Stereoselectivity of the 4-hydroxylation of debrisoquine in man, detected by gas chromatography/mass spectrometry.
A stable isotope assay for the quantification of debrisoquine (1) and its major urinary metabolite 4-hydroxydebrisoquine (2) is… 
Highly Cited
1986
Highly Cited
1986
Altered distribution of debrisoquine oxidation phenotypes in patients with systemic lupus erythematosus.
Oxidative metabolism in patients with systemic lupus erythematosus (SLE) was studied using the antihypertensive drug… 
1986
1986
Liquid chromatographic assay for debrisoquine and 4-hydroxydebrisoquine in urine.
1982
1982
[Drug hydroxylation disorders (debrisoquin type) in a random sample of the Swiss population].
The hydroxylation phenotype was determined in a sample of the Swiss population consisting of 222 normal unrelated subjects (131… 
1981
1981
Debrisoquine hydroxylation capacity: Problems of assessment in two populations
Following the investigation of debrisoquine (D) metaholism to 4‐hydroxydebrisoquine (4OHD) in two populations, problems with the… 
1978
1978
The disposition of debrisoquine in hypertensive patients.
1 The urinary recovery and plasma concentration of debrisoquine (D) and its metabolite 4-hydroxydebrisoquine (HD) has been… 
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