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4-hydroxycyclophosphamide

Known as: 2-(bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-4-ol 2-oxide 
 
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Many agents are active in multiple myeloma, but the majority of patients relapse. This clinical pattern suggests most cancer… Expand
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Highly Cited
2008
Highly Cited
2008
Purpose The anticancer agent, cyclophosphamide, is metabolized by cytochrome P450 (CYP), glutathione S-transferase (GST) and… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Trastuzumab, a humanized anti-HER2 antibody, increases the clinical benefit of first-line chemotherapy in patients… Expand
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Highly Cited
1997
Highly Cited
1997
We have investigated the formation of 4-hydroxycyclophosphamide (HCY) and deschloroethylcyclophosphamide (DCCY) from… Expand
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Highly Cited
1996
Highly Cited
1996
PURPOSE The pharmacokinetics of cyclophosphamide (CY) and 4-hydroxycyclophosphamide (HCY) were studied in 14 patients being… Expand
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Highly Cited
1984
Highly Cited
1984
Plasma half-life and area under the curve (AUC) values for cyclophosphamide were determined in patients given this agent iv at… Expand
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Highly Cited
1982
Highly Cited
1982
  • B. Hales
  • Cancer research
  • 1982
  • Corpus ID: 6882603
Abstract Cyclophosphamide must be metabolically activated to have maximal mutagenic or teratogenic activity. The first step in… Expand
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1980
1980
The metabolism of 4-hydroxycyclophosphamide/aldophosphamide (HCP/AP), the primary metabolitc of cylophosphamide, was studied in… Expand
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Review
1979
Review
1979
SummaryCyclosphosphamide is widely used for cancer chemotherapy and for immunosuppression. The parent compound is inactive in… Expand
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Highly Cited
1974
Highly Cited
1974
Abstract Evidence is presented in support of the following metabolic pathways, in the liver, of the antitumour agent… Expand
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