4-hydroxycyclophosphamide

Known as: 2-(bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-4-ol 2-oxide 
 
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
Many agents are active in multiple myeloma, but the majority of patients relapse. This clinical pattern suggests most cancer… (More)
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2008
2008
PURPOSE The anticancer agent, cyclophosphamide, is metabolized by cytochrome P450 (CYP), glutathione S-transferase (GST) and… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Trastuzumab, a humanized anti-HER2 antibody, increases the clinical benefit of first-line chemotherapy in patients… (More)
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Highly Cited
1996
Highly Cited
1996
PURPOSE The pharmacokinetics of cyclophosphamide (CY) and 4-hydroxycyclophosphamide (HCY) were studied in 14 patients being… (More)
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1996
1996
Using a recently developed gas chromatography and mass spectrometry method to determine whole-blood cyclophosphamide (CP) and 4… (More)
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1995
1995
Cyclophosphamide is a prodrug activated by cytochrome P450 isozymes in the liver. The product of hepatic activation of… (More)
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1991
1991
Pharmacokinetics of 4-hydroxycyclophosphamide (4-OHCP), the major active microsomal metabolite of cyclophosphamide (CP), were… (More)
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1987
1987
4-Hydroxycyclophosphamide (2/3) of unknown stereochemistry is the initial metabolite formed after administration of… (More)
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Highly Cited
1984
Highly Cited
1984
A cyclophosphamide-resistant L1210 cell line has been shown to have unusually high aldehyde dehydrogenase activity. The… (More)
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1983
1983
Male rats were given cyclophosphamide (50 mg/kg, i.p.), and the plasma concentrations of 4-hydroxycyclophosphamide and… (More)
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