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4-chloro-3-hydroxyanthranilic acid

Known as: 4-Cl-3-hana, 4-chloro-3-hydroxyanthranilate, Benzoic acid, 2-amino-4-chloro-3-hydroxy- 
 
National Institutes of Health

Papers overview

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2005
2005
3-Hydroxyanthranilate-3,4-dioxygenase (HAD) is a non-heme Fe(II) dependent enzyme that catalyzes the oxidative ring-opening of 3… Expand
2000
2000
Excitotoxic mechanisms may play a critical role in the pathophysiology of several neurological and psychiatric diseases… Expand
Highly Cited
1995
Highly Cited
1995
Quinolinic acid (QUIN) is an excitotoxic tryptophan metabolite that is produced by activated macrophages. Accumulations of QUIN… Expand
1995
1995
Abstract: The metabolism of l‐tryptophan to the neuroactive kynurenine pathway metabolites, l‐kynurenine, kynurenate and… Expand
1994
1994
Accumulations of the neurotoxin quinolinic acid (QUIN) occur in the brain and blood following immune activation and are… Expand
1994
1994
Quinolinic acid (QUIN) is a potential pathogen in a variety of excitotoxic and neuroviral brain diseases. In the present study… Expand
Highly Cited
1993
Highly Cited
1993
Quinolinic acid (QUIN), kynurenic acid (KYNA) and L-kynurenine (L-KYN) are neuroactive kynurenine pathway metabolites that… Expand
Highly Cited
1990
Highly Cited
1990
Abstract: As assessed by HPLC with electrochemical detection, 3‐hydroxyanthranilic acid (3‐HANA) was found to be present in the… Expand
1988
1988
Quinolinic acid is synthesized from 3-hydroxyanthranilic acid via 3-hydroxyanthranilic acid oxidase. In liver, 4-chloro-3… Expand
1980
1980
Abstract Rats and guinea pigs dosed with dl -6-chlorotryptophan or d -6-chlorotryptophan excrete significantly greater amounts of… Expand