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4'-hydroxywarfarin

Known as: 4-hydroxy-3-(1-(4-hydroxyphenyl)-3-oxobutyl)-2H-1-benzopyran-2-one 
National Institutes of Health

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Broader (1)

Warfarin
analogs & derivatives

Papers overview

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1997
1997
Novel metabolites of warfarin produced by Beauveria bassiana and Streptomyces rimosus: a novel application of hplc-nmr.
1. Biotransformation of warfarin by the fungus Beauveria bassiana (ATCC 7159) yielded the first reported phase II warfarin… 
1992
1992
Phase II metabolism of warfarin in primary culture of adult rat hepatocytes.
We used adult rat hepatocytes in primary culture (HPC) as a model system to study the hepatic phase II metabolism of the… 
1991
1991
Evidence for the stability and cytochrome P450 specificity of the phenobarbital-induced reductive halothane-cytochrome P450 complex formed in rat hepatic microsomes.
1989
1989
Microbial models of mammalian metabolism: conversion of warfarin to 4'-hydroxywarfarin using Cunninghamella bainieri.
Warfarin, an anticoagulant and "metabolic probe" for cytochrome P-450 isozyme multiplicity, is metabolized to 4'-hydroxywarfarin… 
1985
1985
Substrate probes for the mechanism of aromatic hydroxylation catalyzed by cytochrome P-450: selectively deuterated analogues of warfarin.
Optically pure analogues of (R)- and (S)-warfarin selectively deuterated in either the 6-, 7-, or 8-position were prepared and… 
1980
1980
Biliary and urinary excretion of [14C]warfarin in rabbits.
1. The biliary and urinary excretion of racemic [14C]warfarin (1 mg/kg) was studied in male rabbits. 2. In the first 6 h after… 
1979
1979
Warfarin enantiomer disposition: determination by stereoselective radioimmunoassay.
Immunoassay techniques offer promise for the selective analysis of enantiomeric substances without prior separation. In a… 
1976
1976
Warfarin: stereochemical aspects of its metabolism in vivo in the rat.
The biotransformation of the R and S isomers of warfarin was investigated in the rat. The formation of 7-hydroxywarfarin was… 
1975
1975
Studies of the microsomal drug metabolism system in warfarin-resistant and -susceptible rats.
Highly Cited
1970
Highly Cited
1970
The metabolism of 4-C14-warfarin sodium by the rat.
Warfarin and its metabolites were excreted by the rat in urine (two-thirds of the dose) and feces (one-third of the dose). For… 
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