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4'-hydroxyflurbiprofen
National Institutes of Health
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2 relations
Broader (1)
Flurbiprofen
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Biotransformation of Flurbiprofen by Cunninghamella Species
Jessica Amadio
,
K. Gordon
,
C. Murphy
Applied and Environmental Microbiology
2010
Corpus ID: 32012566
ABSTRACT The biotransformation of the fluorinated anti-inflammatory drug flurbiprofen was investigated in Cunninghamella spp…
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2008
2008
Differential Genotype Dependent Inhibition of CYP2C9 in Humans
V. Kumar
,
R. Brundage
,
W. Oetting
,
I. Leppik
,
T. Tracy
Drug Metabolism and Disposition
2008
Corpus ID: 30701683
The effects of genetic polymorphisms in drug-metabolizing enzymes (e.g., CYP2C9*3) on drug clearance have been well characterized…
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2007
2007
Evaluation of flurbiprofen urinary ratios as in vivo indices for CYP2C9 activity.
N. K. Zgheib
,
R. Frye
,
T. Tracy
,
M. Romkes
,
R. Branch
British journal of clinical pharmacology
2007
Corpus ID: 31735613
AIMS We investigated flurbiprofen pharmacokinetics in 12 volunteers to develop a phenotypic trait measure that correlates with…
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2006
2006
Validation of incorporating flurbiprofen into the Pittsburgh cocktail
N. K. Zgheib
,
R. Frye
,
T. Tracy
,
M. Romkes
,
R. Branch
Clinical pharmacology and therapeutics
2006
Corpus ID: 25869474
We have previously shown that flurbiprofen metabolism to 4′‐hydroxyflurbiprofen provides an in vivo measure of cytochrome P450…
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2001
2001
Minimal in vivo activation of CYP2C9-mediated flurbiprofen metabolism by dapsone.
J. Hutzler
,
R. Frye
,
K. Korzekwa
,
R. Branch
,
S. Huang
,
T. Tracy
European journal of pharmaceutical sciences…
2001
Corpus ID: 35269815
Dapsone has been shown to activate flurbiprofen 4'-hydroxylation by expressed CYP2C9 enzyme and in human liver microsomes. It has…
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2000
2000
Sensitive and specific high-performance liquid chromatographic assay for 4'-hydroxyflurbiprofen and flurbiprofen in human urine and plasma.
J. Hutzler
,
R. Frye
,
T. Tracy
Journal of chromatography. B, Biomedical sciences…
2000
Corpus ID: 46037546
A high-performance liquid chromatographic assay has been developed for the simultaneous quantitation of flurbiprofen and its…
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Highly Cited
1993
Highly Cited
1993
Coupling of HPLC with 19F- and 1H-NMR spectroscopy to investigate the human urinary excretion of flurbiprofen metabolites.
M. Spraul
,
M. Hofmann
,
I. Wilson
,
E. Lenz
,
J. Nicholson
,
J. Lindon
Journal of pharmaceutical and biomedical analysis
1993
Corpus ID: 44857061
Results of an on-line HPLC-NMR analysis of human urine from a volunteer administered the anti-inflammatory drug flurbiprofen are…
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1992
1992
Stereoselective disposition of flurbiprofen in normal volunteers.
M. Knadler
,
D. Brater
,
S. Hall
British journal of clinical pharmacology
1992
Corpus ID: 38681889
1. The concentrations of the R- and S-enantiomers of flurbiprofen and its metabolites were measured in plasma and urine following…
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1990
1990
Influence of H2 Receptor Antagonists on the Disposition of Flurbiprofen Enantiomers
R. PharmD
,
Steven R. Cox
,
Wade J. Adams
Journal of clinical pharmacology
1990
Corpus ID: 24148568
The effect of oral cimetidine or ranitidine on the pharmacokinetics of the R and S enantiomers of the nonsteroidal anti…
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1989
1989
High-performance liquid chromatographic analysis of the enantiomers of flurbiprofen and its metabolites in plasma and urine.
M. Knadler
,
S. Hall
Journal of chromatography
1989
Corpus ID: 45555731
Reversed-phase high-performance liquid chromatographic methods have been developed to quantitate the R- and S-enantiomers of…
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