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4'-hydroxyflurbiprofen

 
National Institutes of Health

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Flurbiprofen
analogs & derivatives

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2015
2015
Effect of CYP2C9 genetic polymorphism on the metabolism of flurbiprofen in vitro.
CYP2C9 is an important member of the cytochrome P450 enzyme superfamily, and 57 cytochrome P450 2C9 alleles have been previously… Expand
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2014
2014
Simultaneous determination of flurbiprofen and its hydroxy metabolite in human plasma by liquid chromatography-tandem mass spectrometry for clinical application.
Flurbiprofen (FLB) is one of the phenylalkanoic acid derivatives of non-steroidal anti-inflammatory drugs used for the management… Expand
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2010
2010
Biotransformation of flurbiprofen by Cunninghamella species.
The biotransformation of the fluorinated anti-inflammatory drug flurbiprofen was investigated in Cunninghamella spp. Mono- and… Expand
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2008
2008
Differential genotype dependent inhibition of CYP2C9 in humans.
The effects of genetic polymorphisms in drug-metabolizing enzymes (e.g., CYP2C9(*)3) on drug clearance have been well… Expand
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2007
2007
Evaluation of flurbiprofen urinary ratios as in vivo indices for CYP2C9 activity.
AIMS We investigated flurbiprofen pharmacokinetics in 12 volunteers to develop a phenotypic trait measure that correlates with… Expand
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2006
2006
Validation of incorporating flurbiprofen into the Pittsburgh cocktail.
BACKGROUND We have previously shown that flurbiprofen metabolism to 4'-hydroxyflurbiprofen provides an in vivo measure of… Expand
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2003
2003
Disposition of flurbiprofen in man: influence of stereochemistry and age.
1. The stereoselective metabolism and pharmacokinetics of the enantiomers of flurbiprofen were investigated following the oral… Expand
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2001
2001
Minimal in vivo activation of CYP2C9-mediated flurbiprofen metabolism by dapsone.
Dapsone has been shown to activate flurbiprofen 4'-hydroxylation by expressed CYP2C9 enzyme and in human liver microsomes. It has… Expand
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2000
2000
Sensitive and specific high-performance liquid chromatographic assay for 4'-hydroxyflurbiprofen and flurbiprofen in human urine and plasma.
A high-performance liquid chromatographic assay has been developed for the simultaneous quantitation of flurbiprofen and its… Expand
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1992
1992
Stereoselective disposition of flurbiprofen in normal volunteers.
1. The concentrations of the R- and S-enantiomers of flurbiprofen and its metabolites were measured in plasma and urine following… Expand
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