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4'-hydroxyflurbiprofen

 
National Institutes of Health

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2015
2015
CYP2C9 is an important member of the cytochrome P450 enzyme superfamily, and 57 cytochrome P450 2C9 alleles have been previously… Expand
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2014
2014
Flurbiprofen (FLB) is one of the phenylalkanoic acid derivatives of non-steroidal anti-inflammatory drugs used for the management… Expand
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2010
2010
The biotransformation of the fluorinated anti-inflammatory drug flurbiprofen was investigated in Cunninghamella spp. Mono- and… Expand
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2008
2008
The effects of genetic polymorphisms in drug-metabolizing enzymes (e.g., CYP2C9(*)3) on drug clearance have been well… Expand
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2007
2007
AIMS We investigated flurbiprofen pharmacokinetics in 12 volunteers to develop a phenotypic trait measure that correlates with… Expand
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2006
2006
BACKGROUND We have previously shown that flurbiprofen metabolism to 4'-hydroxyflurbiprofen provides an in vivo measure of… Expand
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2003
2003
1. The stereoselective metabolism and pharmacokinetics of the enantiomers of flurbiprofen were investigated following the oral… Expand
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2001
2001
Dapsone has been shown to activate flurbiprofen 4'-hydroxylation by expressed CYP2C9 enzyme and in human liver microsomes. It has… Expand
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2000
2000
A high-performance liquid chromatographic assay has been developed for the simultaneous quantitation of flurbiprofen and its… Expand
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1992
1992
1. The concentrations of the R- and S-enantiomers of flurbiprofen and its metabolites were measured in plasma and urine following… Expand
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